Targeting Inflammation to Prevent Heart Attacks, Heart Failure, and Cardiovascular Death

Heart disease remains a critical challenge in Australia, particularly within remote and Indigenous communities. Our program investigates atherosclerosis (blocked arteries) and accompanying heart damage. We are testing medicines that could protect the heart during attacks, while developing innovative mRNA-based vaccines and therapeutics to reduce inflammation and prevent plaques in the arteries from rupture. The program will investigate various delivery methods, including nasal sprays, to improve treatment accessibility in remote areas. By targeting the body's inflammatory and immune responses, this research aims to create fairer, more effective ways to prevent and treat heart disease, potentially transforming cardiovascular care for all Australians.