Improving the scalability and reliability of sequencing workflows, better detection of changes in cancer genomes, and aiming to make tumour data accessible in real time.
With a growing need for data management, analysis and research computing Australian Genomic Health Alliance they develop a large-scale Genomics Warehouse built on community standards and support flagship projects with the management and dissemination of data. The group is particularly focused on testing and validating new methods using community-developed benchmarks to improve the chances of detecting relevant somatic genome changes to aid in the diagnostic and treatment of cancer patients.support – in particular due to the unprecedented growth of sequencing data – researchers and clinicians will benefit from community-driven, reusable approaches to process, analyse and aggregate large-scale sequencing data. Professor Hofmann's group is working on improved scalability and reliability of sequencing workflows, better detection of changes in cancer genomes, and aims to make tumour data, especially molecular data, from medical institutions and other organisations, accessible for research use in real time. The group contributes to the development of community-developed workflows to fully automate high throughput sequencing analysis. They reuse existing software and solutions wherever possible to minimise redundant method development. As part of this effort the team works closely with the Global Alliance for Genomics and Health (GA4GH), the Australian BioCommons Human Genomes Platform Project and other partners. As members of the
Contact and more information
Professor Oliver Hofmann
Department of Clinical Pathology