Sex and the broken heart: sex-specific mechanisms driving heart failure

Research Opportunity
Honours students
Number of Honour Places Available
Department / Centre
Baker Department of Cardiometabolic Health
Baker Heart and Diabetes Institute
Primary Supervisor Email Number Webpage
Dr Alexander Pinto +61385321275
Co-supervisor Email Number Webpage
Dr Malathi Dona +61385321111

Summary Until recently the cellular composition of the heart was poorly defined. Using advanced genetic, cytometric and single cell transcriptomic approaches, our research has shed new light on the cellular constituents of the heart, demonstrating that the heart is comprised of a complex ecosystem of cell types. Furthermore, we have recently found that the cellular landscape of the heart is sexually dimorphic in terms of cell abundance, gene expression and stress responses. By combining computational biology, single-cell omics, mouse genetics and refined 2D and 3D imaging methodologies, this project aims to determine sex-specific mechanisms driving heart heart failure.

Faculty Research Themes

Child Health, Infection and Immunology

School Research Themes

Child Health in Medicine, Ageing, Cancer in Medicine, Cardiometabolic

Research Opportunities

Honours students
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department / Centre

Baker Department of Cardiometabolic Health

Research Node

Baker Heart and Diabetes Institute

MDHS Research library
Explore by researcher, school, project or topic.