Mineralocorticoid receptor activation pathways in macrophages ; new mechanisms of heart failure

Research Opportunity
Honours students
Number of Honour Places Available
Department / Centre
Baker Department of Cardiometabolic Health
Baker Heart and Diabetes Institute
Primary Supervisor Email Number Webpage
Associate Professor Morag Young morag.young@baker.edu.au 03 8532 1111 Personal web page

Summary The mineralocorticoid receptor (MR) is best known for regulating sodium, potassium, fluid balance and blood pressure control via actions in the kidney. Our work has shown that the MR also has important functional roles in other tissues and cell types including cardiac myocytes, vascular smooth muscle cells and inflammatory cells such as macrophages. In these cells, the actions of the MR play a central role cardiac inflammation and fibrosis, which, are hall marks of heart disease.

Project Details

The goal of these studies is to identify novel MR regulated pathways using proteomic and genomic screening technologies and to define and characterise these pathways using human and mouse cell lines, preclinical and transgenic models, and clinical samples where possible.
In this way, we hope to identify novel mechanisms of heart disease, determine the optimal way to treat patients and avoid the serious side effects of current treatments.
Techniques involved: tissue culture, molecular cloning techniques, cytokine assays, RTPCR, western blot, FACS, immunocytochemistry, bioinformatics, database analyses.

School Research Themes


Research Opportunities

Honours students
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department / Centre

Baker Department of Cardiometabolic Health

Research Node

Baker Heart and Diabetes Institute

MDHS Research library
Explore by researcher, school, project or topic.