Cellular and Molecular Mechanisms Driving Anthracycline-Induced Cardiotoxicity in Children
- Research Opportunity
- Honours students
- Number of Honour Places Available
- Department / Centre
- Baker Department of Cardiometabolic Health
- Baker Heart and Diabetes Institute
|Dr Alexander Pintoemail@example.com||85321111||Personal web page|
|Dr Malathi Donafirstname.lastname@example.org||85321111||Personal web page|
Summary Anthracyclines such as doxorubicin are effective chemotherapeutic agents for treating childhood cancers with a survival rate of 84% in Australia . More recently however, it has been reported that survivors treated with doxorubicin during childhood risk a 6-10 fold increased incidence of developing early onset heart failure. By applying advanced genetic, flow cytometric, imaging and single cell transcriptomic approaches, the aim of this project is to determine the impact of doxorubicin on the cardiac cellular landscape and the development of pathological cardiac remodelling. Specifically, this project will test the hypothesis that doxorubicin age- and sex-specifically remodels the cardiac cellular landscape.
Faculty Research Themes
School Research Themes
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.
Department / Centre
Research NodeBaker Heart and Diabetes Institute
MDHS Research library
Explore by researcher, school, project or topic.