Adaptive Platform Trials
MCCT is proud to be part of a new era in clinical research with adaptive platform trials.
These trials can study several therapies at once and evolve as results come in by dropping what doesn’t work and focusing on what does. That means better care for patients, quicker answers for researchers and more efficient use of resources. It’s an exciting and cutting-edge approach that’s transforming how we improve healthcare.
ASCOT
Is finding fast and effective COVID-19 treatments to reduce deaths and ventilation needs in hospitalised patients before they become critically ill.
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BANDICOOT
This study tests multiple supportive care approaches in one trial to find what helps children recover best after a stem cell transplant. It aims to improve wellbeing now and build a stronger system for future research.
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PASSPORT
This study brings multiple sepsis treatments into one trial. It evolves over time to provide the most effective care to the participant.
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PLATIPUS
Is a world-first clinical trial that aims to improve the health of babies born and at risk of being born prematurely.
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SEAMLESS
This research tests new stroke treatments by building a national study using a flexible trial design to improve care and outcomes for patients across Australia.
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SNAP
This international trial is working with both adults and children to find better treatments for serious bloodstream infections caused by Staphylococcus aureus.
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SNAP Trial
The SNAP study is being conducted at sites across Australia, New Zealand, Singapore, Malaysia, Canada, Israel, South Africa, Japan, Europe, the USA and the UK. To support other researchers, the SNAP team has made many of their key study documents publicly available. These include the core protocol, statistical analysis plan, registry appendix and domain specific appendices.
Access ResourcesPLATIPUS Trial
PLATIPUS is preparing to begin participant recruitment by the end of 2026. As part of their commitment to supporting future research, the team has shared their core study protocol for others to use as a guide when developing new studies. The protocol provides practical examples of study design, governance, and operational planning that may be useful for researchers developing similar trials.
Access ResourcesEU-PEARL
EU-PEARL is a European partnership that has developed a range of tools and resources to support collaborative platform trials. These materials can be a valuable starting point for researchers planning an adaptive platform trial. As the resources were developed for the European regulatory environment, some information may not fully align with Australian requirements.
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