Colorectal Oncogenomics
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Why are more young people getting colorectal cancer? | Prof Mark Jenkins & A/Prof Dan Buchanan
The incidence of colorectal cancer in young adults is increasing in many westernised countries including Australia, the cause of which is currently unknown. Detailing the mutational processes in the tumour could hold the key to unlocking this public health problem.
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Resolving Suspected Lynch Syndrome Cases to Improve Risk Stratification | Romy Walker
An improved approach to resolve DNA mismatch repair deficient colorectal and endometrial cancers classified as suspected Lynch syndrome through targeted tumour sequencing and multiple MLH1 promoter methylation assays.
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Characterisation of the Young Onset Colorectal Cancer tumour microenvironment | Ryan Hutchinson
The application of tissue-based biomarker assays and state of the art computational pathology approaches to generate additional insights into young onset colorectal cancer.
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Evaluating the clinical applicability of tumour mutational signatures in colorectal cancer
Peter investigates the effectiveness of tumour mutational signatures for identifying and understanding sub-types of CRC by describing specific use-cases where signatures can enhance current knowledge, highlighting both their suitability and limitations.
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Resolving Suspected Lynch Syndrome Cases to Improve Risk Stratification
In this seminar Romy presents the application of a novel targeted tumour sequencing approach that can accurately resolve inherited from sporadic aetiology, providing an evidence base for its translation into clinical practice.