All Department 2019 projects

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Projects Title Project Site Department Short Summary Project Description Number of Honour Places Available Number of Master Places Available Primary Supervisor Title Primary Supervisor First Name Primary Supervisor Surname Primary Supervisor Email Co-Supervisor 1 Title Co-Supervisor 1 First Name Co-Supervisor 1 Surname Opportunity
A novel link between metabolism and host defence: O-GlcNAc glycosylation Bio21 Molecular Science and Biotechnology Institute Biochemistry and Molecular Biology N/A 2 Professor Jose Villadangos j.villadangos@unimelb.edu.au Dr Justine Mintern PhD; Masters by Research; Honours; Master of Biomedical Science
Alternative splicing in human parasites Bio21 Molecular Science and Biotechnology Institute Biochemistry and Molecular Biology N/A Stuart Ralph saralph@unimelb.edu.au PhD; Masters by Research; Honours; Master of Biomedical Science
Analysing protein structures Bio21 Molecular Science and Biotechnology Institute Biochemistry and Molecular Biology N/A Dr David Ascher david.ascher@unimelb.edu.au PhD; Masters by Research; Honours; Master of Biomedical Science
Can drug-like mimetics of BDNF promote remyelination after injury? Medical Building Anatomy and Neuroscience This project aims to investigate whether we can develop methods to selectively and independently activate either TrkB or p75NTR, and use these to promote myelin repair in vivo. N/A Dr Junhua Xiao xiaoj@unimelb.edu.au PhD; Masters by Research; Honours; Master of Biomedical Science
Characterisation of the changes of the endocytic and secretory pathway of dendritic cells upon activation Bio21 Molecular Science and Biotechnology Institute Biochemistry and Molecular Biology N/A 1 Associate Professor Isabelle Rouiller isabelle.rouiller@unimelb.edu.au Masters by Research; Honours; Master of Biomedical Science
Decoding the trafficking of immune receptors Bio21 Molecular Science and Biotechnology Institute Biochemistry and Molecular Biology N/A Dr Justine Mintern jmintern@unimelb.edu.au Professor Jose Villadangos PhD; Honours; Master of Biomedical Science
Dental morphology Anatomy and Neuroscience Dental morphology research in the lab addresses the question of the reliability of teeth for determining the evolutionary relationships among human ancestors. N/A Dr Varsha Pilbrow vpilbrow@unimelb.edu.au PhD; Masters by Research; Honours; Master of Biomedical Science
Designing better drugs Bio21 Molecular Science and Biotechnology Institute Biochemistry and Molecular Biology N/A Dr David Ascher david.ascher@unimelb.edu.au PhD; Masters by Research; Honours; Master of Biomedical Science
Designing new optogenetic tools for biomedical research Bio21 Molecular Science and Biotechnology Institute Biochemistry and Molecular Biology N/A 1 A/Prof Danny Hatters dhatters@unimelb.edu.au Dr Craig Morton PhD; Masters by Research; Honours
Development and application of soft culturing microenvironment for novel drug discovery Pharmacology and Therapeutics N/A Professor Alastair Stewart astew@unimelb.edu.au Masters by Research; Honours; Master of Biomedical Science
Development of Novel antimalarial drugs Bio21 Molecular Science and Biotechnology Institute Biochemistry and Molecular Biology N/A Professor Leann Tilley ltilley@unimelb.edu.au PhD; Masters by Research; Honours
Exploiting nanoparticles as vaccines Bio21 Molecular Science and Biotechnology Institute Biochemistry and Molecular Biology N/A Dr Justine Mintern jmintern@unimelb.edu.au Professor Jose Villadangos PhD; Honours; Master of Biomedical Science
Finding clarity within a blizzard- guiding the solution of cryo-EM structures Bio21 Molecular Science and Biotechnology Institute Biochemistry and Molecular Biology N/A Dr David Ascher david.ascher@unimelb.edu.au PhD; Masters by Research; Honours; Master of Biomedical Science
Glucocorticoid responsiveness in the lung: impact of inflammation and infection Pharmacology and Therapeutics N/A Professor Alastair Stewart astew@unimelb.edu.au Masters by Research; Honours; Master of Biomedical Science
How do dietary nutrients affect the ability of stem cells and stem cell-derived tumours to grow and divide? Peter MacCallum Cancer Institute Anatomy and Neuroscience The effect of diet on stem cell proliferation and tumour growth is poorly characterised. Using a chemically defined diet together with metabolomic approaches, we are interested in identifying metabolic alterations associated with dedifferentiation, stem cell reactivation and cancer. N/A Dr Louise Cheng lcheng1@unimelb.edu.au PhD; Masters by Research; Honours
How do neurons maintain their specialised status? Peter MacCallum Cancer Institute Anatomy and Neuroscience The lab is interested in identifying novel transcription factors that regulate this process, and investigate whether these factors are involved in regeneration. N/A Dr Louise Cheng lcheng1@unimelb.edu.au PhD; Masters by Research; Honours
How do tumours compete with other tissues for resources? Peter MacCallum Cancer Institute Anatomy and Neuroscience During cancer cachexia, tumours secrete signals to break down muscle and fat to promote its own growth, we are interested in the organ-crosstalk, and the signalling events which lead to organ-competition. N/A Dr Louise Cheng lcheng1@unimelb.edu.au PhD; Masters by Research; Honours
How early life experience influences brain myelination and function late in life? Medical Building Anatomy and Neuroscience This project will involve the analysis as to whether and how altering brain activity influences the oligodendroglial cell dynamics and myelin integrity in the adolescent, adult or aging brains, in particular how early life experience influences brain myelination and function late in life. N/A Dr Junhua Xiao xiaoj@unimelb.edu.au PhD; Masters by Research; Honours; Master of Biomedical Science
How infection and trauma cause dendritic cell paralysis and lethal immunosuppression Doherty Institute Microbiology and Immunology N/A 2 Professor Jose Villadangos j.villadangos@unimelb.edu.au Dr Justine Mintern PhD; Masters by Research; Honours; Master of Biomedical Science
How to harness the immune system to cure cancer: adoptive cell immunotherapy Doherty Institute Microbiology and Immunology N/A 2 Professor Jose Villadangos j.villadangos@unimelb.edu.au Dr Justine Mintern PhD; Masters by Research; Honours; Master of Biomedical Science
Immunoregulatory functions of the MARCH family of ubiquitin ligases Bio21 Molecular Science and Biotechnology Institute Biochemistry and Molecular Biology N/A 2 Professor Jose Villadangos j.villadangos@unimelb.edu.au Dr Justine Mintern PhD; Masters by Research; Honours; Master of Biomedical Science
Improving the diagnostic outcomes of patients with mitochondrial disease Bio21 Molecular Science and Biotechnology Institute Biochemistry and Molecular Biology N/A 1 Dr David Stroud david.stroud@unimelb.edu.au PhD; Masters by Research; Honours; Master of Biomedical Science
Investigating mechanisms of protein trafficking to human mitochondria Bio21 Molecular Science and Biotechnology Institute Biochemistry and Molecular Biology N/A Dr Diana Stojanovski d.stojanovski@unimelb.edu.au PhD; Masters by Research; Honours
Investigating the molecular basis of central myelination and repair Medical Building Anatomy and Neuroscience This project will involve the analysis of the myelin-forming oligodendrocytes and their capacity of myelin repair as well as functional recovery in cell-type specific mouse mutant in combination with animal models of demyelinating diseases. N/A Dr Junhua Xiao xiaoj@unimelb.edu.au PhD; Masters by Research; Honours; Master of Biomedical Science
Malaria parasite-infected red blood cells: a renovator’s dream Bio21 Molecular Science and Biotechnology Institute Biochemistry and Molecular Biology N/A Professor Leann Tilley ltilley@unimelb.edu.au Dr Adam Blanch PhD; Masters by Research; Honours
Manipulating immunity to fight infection and tumours Bio21 Molecular Science and Biotechnology Institute Biochemistry and Molecular Biology N/A Dr Justine Mintern jmintern@unimelb.edu.au Professor Jose Villadangos PhD; Honours; Master of Biomedical Science
Manipulating the endocannabinoid system to alter cardiovascular function in hypertension Pharmacology and Therapeutics N/A Dr Makhala Khammy mmkhammy@unimelb.edu.au A/Prof Christine Wright PhD; Masters by Research; Honours; Master of Biomedical Science
Mapping the proteome vulnerable to unfolding and aggregation under proteostasis stress Bio21 Molecular Science and Biotechnology Institute Biochemistry and Molecular Biology N/A 1 A/Prof Danny Hatters dhatters@unimelb.edu.au Prof Gavin Reid PhD; Masters by Research; Honours
MR1 – a molecular alarm system that detects pathogen metabolites Doherty Institute Microbiology and Immunology N/A 2 Professor Jose Villadangos j.villadangos@unimelb.edu.au Dr Justine Mintern PhD; Masters by Research; Honours; Master of Biomedical Science
Mummy Studies Anatomy and Neuroscience This project brings together the fields of topographic anatomy, biological anthropology, bioarchaeology, digital analysis and Egyptology. N/A Dr Varsha Pilbrow vpilbrow@unimelb.edu.au PhD; Masters by Research; Honours; Master of Biomedical Science
Personalising treatments for genetic diseases Bio21 Molecular Science and Biotechnology Institute Biochemistry and Molecular Biology N/A Dr David Ascher david.ascher@unimelb.edu.au PhD; Masters by Research; Honours; Master of Biomedical Science
Principles of Peripheral Nerve Myelination Medical Building Anatomy and Neuroscience In this project, we are interested in analysing the timing and extent of Schwann cell proliferation and migration, their mode of migration, how myelin responds to the lengthening peripheral nerve, and the generation and maintenance of myelin lipids. N/A Dr Simon Murray ssmurray@unimelb.edu.au PhD; Masters by Research; Honours; Master of Biomedical Science
Protein trafficking and cellular architecture Bio21 Molecular Science and Biotechnology Institute Biochemistry and Molecular Biology N/A Professor Leann Tilley ltilley@unimelb.edu.au PhD; Masters by Research; Honours
Rational Protein Engineering Bio21 Molecular Science and Biotechnology Institute Biochemistry and Molecular Biology N/A Dr David Ascher david.ascher@unimelb.edu.au PhD; Masters by Research; Honours; Master of Biomedical Science
Sex in human malaria parasites Bio21 Molecular Science and Biotechnology Institute Biochemistry and Molecular Biology N/A 2 Dr Matthew Dixon matthew.dixon@unimelb.edu.au Professor Leann Tilley PhD; Masters by Research; Honours; Master of Biomedical Science
Skeletal morphology Anatomy and Neuroscience Research on skeletal morphology focuses on change in the human skeleton in response to genetic drift, mutation, adaptation and interaction with the physical and biological environment. N/A Dr Varsha Pilbrow vpilbrow@unimelb.edu.au PhD; Masters by Research; Honours; Master of Biomedical Science
Small molecules for BIG targets- Targeting protein-protein interactions with fragments Bio21 Molecular Science and Biotechnology Institute Biochemistry and Molecular Biology N/A Dr David Ascher david.ascher@unimelb.edu.au PhD; Masters by Research; Honours; Master of Biomedical Science
Solving the native structure of the malaria parasite using cryo-electron microscopy Bio21 Molecular Science and Biotechnology Institute Biochemistry and Molecular Biology N/A Professor Leann Tilley ltilley@unimelb.edu.au A/Prof. Eric Hanssen PhD; Masters by Research; Honours
Structural Biology of Cancer Bio21 Molecular Science and Biotechnology Institute Biochemistry and Molecular Biology N/A Professor Michael Parker mwp@unimelb.edu.au PhD; Honours
Structural Biology of Infection Bio21 Molecular Science and Biotechnology Institute Biochemistry and Molecular Biology N/A Professor Michael Parker mwp@unimelb.edu.au PhD; Honours
Structural Neurobiology Bio21 Molecular Science and Biotechnology Institute Biochemistry and Molecular Biology N/A Professor Michael Parker mwp@unimelb.edu.au PhD; Honours
Tackling drug resistance Bio21 Molecular Science and Biotechnology Institute Biochemistry and Molecular Biology N/A Dr David Ascher david.ascher@unimelb.edu.au PhD; Masters by Research; Honours; Master of Biomedical Science
The amyloidogenic protease inhibitor Cystatin C in health and disease Bio21 Molecular Science and Biotechnology Institute Biochemistry and Molecular Biology N/A 2 Prof. Jose Villadangos j.villadangos@unimelb.edu.au Dr. Justine Mintern PhD; Masters by Research; Honours; Master of Biomedical Science
The role of mitochondria in Coxiella burnetii infection Bio21 Molecular Science and Biotechnology Institute Biochemistry and Molecular Biology N/A Dr Diana Stojanovski d.stojanovski@unimelb.edu.au Dr Hayley Newton PhD; Masters by Research; Honours
Treating the person not the disease Bio21 Molecular Science and Biotechnology Institute Biochemistry and Molecular Biology N/A Dr David Ascher david.ascher@unimelb.edu.au PhD; Masters by Research; Honours; Master of Biomedical Science
Understanding how Anthrax toxins function Bio21 Molecular Science and Biotechnology Institute Biochemistry and Molecular Biology N/A Associate Professor Isabelle Rouiller isabelle.rouiller@unimelb.edu.au PhD; Masters by Research
Understanding how membrane-less organelles form with optogenetic tools Bio21 Molecular Science and Biotechnology Institute Biochemistry and Molecular Biology N/A A/Prof Danny Hatters dhatters@unimelb.edu.au Dr Dezerae Cox PhD; Masters by Research; Honours
Understanding how the ATPase p97 functions at molecular level Bio21 Molecular Science and Biotechnology Institute Biochemistry and Molecular Biology N/A 2 Associate Professor Isabelle Rouiller isabelle.rouiller@unimelb.edu.au PhD; Masters by Research; Honours; Master of Biomedical Science
Understanding immune dysfunction in acute myeloid leukemia Bio21 Molecular Science and Biotechnology Institute Biochemistry and Molecular Biology N/A Dr Justine Mintern jmintern@unimelb.edu.au Professor Jose Villadangos PhD; Honours; Master of Biomedical Science
Understanding the assembly of mitochondrial machines Bio21 Molecular Science and Biotechnology Institute Biochemistry and Molecular Biology N/A 2 Dr David Stroud david.stroud@unimelb.edu.au PhD; Masters by Research; Honours; Master of Biomedical Science
Understanding the Molecular Consequences of Mutations Bio21 Molecular Science and Biotechnology Institute Biochemistry and Molecular Biology N/A Dr David Ascher David Ascher david.ascher@unimelb.edu.au PhD; Masters by Research; Honours; Master of Biomedical Science
Using the immune system to kill tumours Bio21 Molecular Science and Biotechnology Institute Biochemistry and Molecular Biology N/A Dr Justine Mintern jmintern@unimelb.edu.au Professor Jose Villadangos PhD; Honours; Master of Biomedical Science
“Clock-off time” for inflammation and remodelling in chronic inflammatory diseases: casein kinase inhibitors Pharmacology and Therapeutics N/A Professor Alastair Stewart astew@unimelb.edu.au Masters by Research; Honours; Master of Biomedical Science