You are what you eat? The gut microbiome and its regulation of heart disease
- Research Opportunity
- PhD students, Masters by Research, Honours students
- Baker Department of Cardiometabolic Health
- Baker Heart and Diabetes Institute
|Dr Yung-Chih Chenemail@example.com||Personal web page|
Summary Can the gut microbiome be modulated as a treatment to reduce the risk of cardiovascular disease?
Cardiovascular disease (CVD) is the major cause of disability and death worldwide. It is typically caused by the rupture of atherosclerotic plaques in coronary arteries. The whole-genome human microbiome project revealed the diversity of microbes and identified many genes across various body parts and their fundamental roles in human health and disease. Recent clinical studies have demonstrated that circulating Trimethylamin N-oxide (TMAO) levels are associated with an increased risk of major adverse cardiovascular events.
Interestingly, gut bacteria are known to metabolize TMA as their growth factor and convert TMA to TMAO. Unsurprisingly, diets rich in carnitine, lecithin and choline are positively correlated to plasma TMAO levels. Nevertheless, the mechanism of how TMAO affects atherosclerosis is less clear. We would like to investigate this missing link by using our novel animal model of plaque instability and a novel compound to inhibit the TMAO production.
Students involved in this project will be trained in essential skills in atherosclerotic studies and basic histology. Basic molecular biology training will also provided. Further training in small animal imaging and molecular imaging is also possible for potential PhD students.
School Research Themes
PhD students, Masters by Research, Honours students
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.
Research NodeBaker Heart and Diabetes Institute
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