What role does Bax play during gonocyte transformation into spermatogonial stem cells?

Research Opportunity
Honours, Master of Biomedical Science
Number of Honour Places Available
1
Number of Master Places Available
1
Department
Paediatrics
Primary Supervisor Email Number Webpage
Doctor Ruili Li ruili.li@mcri.edu.au 99366757 Personal web page
Co-supervisor Email Number Webpage
Professor John Hutson john.hutson@mcri.edu.au 93455808 Personal web page

Summary This study will use mouse model to examine the role of an apoptosis regulator, Bax, in removing persisting gonocytes from the testicular tubules so that they do not mutate into CIS cells and testicular seminomas after puberty. The study will involve use mouse flow cytometry immunohistochemistry with molecular markers and confocal microscopy.

Project Details

Congenital undescended testis (UDT), or cryptorchidism, affects 2-4% of newborn boys and leads to a 5-10 fold increase in testicular cancer (seminoma), and 30-60% risk of infertility.  Seminomas in young men with UDT arise from immature germ cells which failed in both transformation into spermatogonial stem cells (SSC) and apoptosis. We propose that persisting neonatal germ cells (gonocytes) are the results of gonocytes that failed to transform into SCC or failed to disappear by apoptosis. This study will use mouse model to examine the role of an apoptosis regulator, Bax, in removing persisting gonocytes from the testicular tubules so that they do not mutate into CIS cells and testicular seminomas after puberty. The study will involve use mouse flow cytometry immunohistochemistry with molecular markers and confocal microscopy.



Faculty Research Themes

Child Health

School Research Themes

Child Health in Medicine



Research Opportunities

Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Paediatrics


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