What kind of antibody response to women need to be protected from placental malaria?
- Research Opportunity
- Number of Honour Places Available
- Medicine and Radiology
- Royal Melbourne Hospital
|Elizabeth Aitkenfirstname.lastname@example.org||0383441972||Personal web page|
|Stephen Rogersonemail@example.com||Personal web page|
Pregnant women are susceptible to malaria and though we know which antigen women’s antibodies need to recognize, we don’t know the most efficient way for these antibodies to protect women. Antibody responses can vary dramatically in nature and may confer protection in a variety of ways. This project would involve measuring a specific aspect of the immune response towards placental malaria antigen, in samples from pregnant women and/or individuals from Phase I vaccine trials and analyzing if they are protective or if they are generated. This will help us identify the role of individual aspects of immunity in protection, information needed to effectively design and evaluate a pregnancy-malaria vaccine. This project will involve a combination of 2 or more of the following methods solid phase immunoassays, cell based immunoassays, flow cytometry, cell culture, microcopy & statistical analysis.
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