Vitamin C concentrations following aneurysmal subarachnoid haemorrhage

Research Opportunity
Honours students
Number of Honour Places Available
1
Department / Centre
Medicine and Radiology
Location
Royal Melbourne Hospital
Primary Supervisor Email Number Webpage
Associate Professor Adam Deane adam.deane@mh.org,au 0431967560 Personal web page
Co-supervisor Email Number Webpage
Dr Mark Plummer mark.plummer@mh.org.au 0419708399
Dr Yasmine Ali Abdelhamid yasmine.aliabdelhamid@mh.org.au 0416186874

Summary A prospective interventional study to understand whether vitamin C concentrations in plasma and CSF are reduced following aneurysmal subarachnoid haemorrhage.

Project Details

Subarachnoid haemorrhage (SAH) occurs when a weakened blood vessel in the brain (cerebral aneurysm) ruptures. This form of stroke affects approximately 2,500 Australians each year and has devastating consequences. Outcomes for patients after this type of stroke (aneurysmal subarachnoid haemorrhage, aSAH) are generally poor, with a high level of death and disability. Moreover, aSAH affects a younger demographic compared to other stroke subtypes leading to increased loss of productive years.

Vasospasm is the leading modifiable cause of poor outcome following aSAH. The term 'vasospasm' implies the constriction or uncontrolled spasm of blood vessels in the brain. Cerebral vasospasm develops in approximately two-thirds of patients following SAH, which may progress to further permanent brain injury, i.e. secondary stroke due to vasospasm. Accordingly, prevention of vasospasm and these secondary strokes remains the key target for novel treatments following aSAH.

At present, the only treatment that reduces secondary stokes is a blood pressure drug, nimodipine. This drug is now routinely administered to patients with aSAH.

Vitamin C is safe and inexpensive and when administered in pharmacological doses it dilates blood vessels and protects brain cells. However, these effects have never been assessed in patients following aSAH. 

Given the paucity of interventions to prevent vasospasm and the neuroprotective properties of vitamin C we wish to conduct an interventional study to evaluate whether vitamin C levels in the blood and brain are associated with vasospasm. If this study demonstrates that endogenous concentrations are reduced this would provide a rationale to trial intravenous supplementation of vitamin C in this patient population.



Faculty Research Themes

Neuroscience

School Research Themes

Neuroscience & Psychiatry, Integrated Critical Care in Medicine



Research Opportunities

Honours students
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department / Centre

Medicine and Radiology

Research Node

Royal Melbourne Hospital

MDHS Research library
Explore by researcher, school, project or topic.