Uterine dysfunction in Recurrent miscarriage

Research Opportunity
Masters by Research, Honours, Master of Biomedical Science
Department
Obstetrics and Gynaecology
Location
Royal Women’s Hospital
Primary Supervisor Email Number Webpage
Dr Ellen Menkhorst ellen.menkhorst@unimelb.edu.au 0437774353 Personal web page
Co-supervisor Email Number Webpage
Professor Eva Dimitriadis eva.dimitriadis@unimelb.edu.au Personal web page

Summary Recurrent miscarriage is thought to be caused by an impaired maternal response to the pregnancy within the uterus. This project will define how the remodelled uterus promotes the formation of a healthy placenta and the establishment of maternal immune tolerance towards the fetus.

Project Details

Miscarriage is the most common obstetric complication, affecting ~15% of all pregnancies. Recurrent miscarriage will affect 2% of all pregnancies and is defined as 3 or mor esequential miscarriages prior to 20 weeks gestation. Using current evidence-based tests for evaluation of couples with recurrent miscarriage, only about 60% of couples will have an cause identified, leaving many couples without a definitive diagnosis and no specific treatment options.It is thought that impaired uterine function and poor implantation and placentation during the establishment of pregnancy is a causal factor of unexplained recurrent miscarriage. However, the reasons why uterine function is impaired are not well understood and currently we are not easily able to identify impaired uterine function in women with recurrent miscarriage.This study will define the function of uterine microRNAs that are altered in women with recurrent miscarriage and assess whether these factors have clinical utility as diagnostic or therapeutic targets.



Faculty Research Themes

Child Health

School Research Themes

Child Health in Medicine, Women's Health



Research Opportunities

Masters by Research, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Obstetrics and Gynaecology

Research Node

Royal Women’s Hospital

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