Using the JAK1/JAK2 Inhibitor Baricitinib to treat new-onset Type 1 diabetes
- Research Opportunity
- PhD, Masters by Research, Master of Biomedical Science
- Number of Master Places Available
- Medicine and Radiology
- St Vincent's Institute of Medical Research
|Prof Helen Thomasfirstname.lastname@example.org||+61 3 9231 3282|
|Prof Tom Kayemail@example.com|
Summary The goal of this project is to investigate whether the JAK inhibitor baricitinib dampens autoimmunity and preserves beta cell function in human type 1 diabetes.
Our goal is to prevent the immune-mediated destruction of insulin-producing pancreatic beta cells that leads to type 1 diabetes. The JAK-STAT signalling pathway is critical for immune-mediated pancreatic beta cell destruction. We have shown that inhibitors of JAK1/JAK2 prevent diabetes and also reverse newly diagnosed diabetes in the non-obese diabetic (NOD) mouse model of type 1 diabetes. The goal of this project is to investigate whether the JAK inhibitor baricitinib dampens autoimmunity and preserves beta cell function in human type 1 diabetes.
We plan to conduct a placebo-controlled trial to investigate the safety and efficacy of baricitinib in 83 individuals aged 12-30 years with recent-onset type 1 diabetes. The primary objective is to determine if baricitinib can reduce the loss of meal-stimulated C-peptide, a measure of beta-cell function. As exploratory objectives, we plan to evaluate the impact of baricitinib on type 1 diabetes-associated immune responses. To achieve this, we will use two complementary approaches, single-cell proteomics and single-cell transcriptomics. We hypothesise that baricitinib will induce intra-individual and inter-individual changes in immune cells. Single-cell RNA-seq will capture the biological pathways altered by baricitinib while mass cytometry will be used to capture the phenotypical and functional differences between cells.
School Research Themes
PhD, Masters by Research, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.
Research NodeSt Vincent's Institute of Medical Research
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