Using pluripotent stem cells to model AMD

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Number of Honour Places Available
1
Department
Surgery
Location
Surgery, Ophthalmology, Royal Victorian Eye and Ear Hospital
Primary Supervisor Email Number Webpage
A/Prof Alice Pebay apebay@unimelb.edu.au Personal web page

Project Details

Age-related macular degeneration (AMD) is the leading cause of blindness in the developed world. Virtually nothing is known about how or why retinal cells die in AMD; however, genetic background is a significant risk factor. Our research uses stem cells from patients with eye diseases to better understand the underlying cause of diseases. In this project, we will reprogram skin and hair cells from these patients with specific genetic risk associated with AMD into induced pluripotent stem cells, and then drive the stem cells to become retinal pigmented epithelial cells to create an in vitro model in which to study AMD pathogenesis. By examining how these retinal cells die, we expect to find ways to block this process, which is an important step towards developing therapies.

This project is conducted in Centre for Eye Research Australia, Neuroregeneration Unit.


School Research Themes

Ageing



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Surgery

Research Node

Surgery, Ophthalmology, Royal Victorian Eye and Ear Hospital

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