Using Marrow Adipose Tissue to Diagnose Osteoporosis and Predict Fragility Fractures

Research Opportunity
PhD students, Masters by Research, Honours students
Number of Honour Places Available
1
Number of Master Places Available
1
Department / Centre
Medicine and Radiology
Location
Western Health
Primary Supervisor Email Number Webpage
Professor Gustavo Duque gustavo.duque@unimelb.edu.au Personal web page
Co-supervisor Email Number Webpage
Dr Ebrahim Bani Hassan ebrahim.bani@unimelb.edu.au Personal web page

Summary Yearly 144,000 osteoporotic Australians fracture, that costs circa $4 billion. If fracture (Fx) risk is identified early, most Fx are preventable.

Project Details

Osteoporosis (OP) diagnosis and Fx risk estimation mostly relies on bone mineral density (BMD). However, up to 82% of people with Fx are not osteoporotic according to their BMD (T-scores> -2.5). Hence, they are not classified at risk of Fx and treated. Also, BMD improvement due to OP treatment does not explain >75% of reductions in Fx risk. Therefore, sensitive, specific and non-invasive methods for predicting Fx are mandatory.

In aged and osteoporotic bone, high levels of marrow adipose tissue (MAT) is a common observed feature. There is strong evidence that MAT expansion drives bone and red marrow atrophy by inducing a lipotoxic milieu that affects tissues in its vicinity; which is associated with altered matrix synthesis, abnormal mineralization, and reduced bone formation and mechanical resistance. MAT is inversely correlated with bone and unlike BMD can provide indirect information on other aspects of bone structure/strength, e.g. osteoblast health, collagen crosslinks and bone formation; and hence can act as a predictor of Fx.

Therefore, through two related studies we will: 1. Validate prediction of Fx risk using MAT and test its higher predictive value compared to BMD; 2. Identify the best imaging technologies that non-invasively, accurately and affordably quantify bone, red marrow and MAT volume.


School Research Themes

Ageing, Musculoskeletal



Research Opportunities

PhD students, Masters by Research, Honours students
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department / Centre

Medicine and Radiology

Research Node

Western Health

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