Unravelling the Inflammatory Signatures of Paediatric Respiratory Disease

Research Opportunity
PhD students
Department / Centre
Paediatrics
Location
Royal Children’s Hospital/Murdoch Childrens Research Institute
Primary Supervisor Email Number Webpage
Dr Melanie Neeland melanie.neeland@mcri.edu.au Personal web page
Co-supervisor Email Number Webpage
Prof Sarath Ranganathan sarath.ranganathan@rch.org.au Personal web page

Summary Unravelling the Inflammatory Signatures of Paediatric Respiratory Disease

Project Details

Inflammation is a key aspect of the pathophysiology of many common paediatric respiratory diseases, but very little is known about the exact inflammatory pathways that define different diseases. A better understanding of the inflammatory signature of different paediatric respiratory diseases would help to identify novel therapeutic targets and predictive biomarkers.

In this PhD you will have the opportunity to work as part of a larger study that is aiming to define the inflammatory signatures of common diseases such as asthma/wheeze, acute lower respiratory tract infections, lung disease of prematurity and bronchiectasis. What is unique and world leading about this project is the use of tissue specific samples (bronchoalveolar lavage and bronchial brushings). The exact focus of the PhD can be determined, but broadly speaking your PhD would involve laboratory experience with techniques such as flow cytometry and single cell RNA sequencing, and bioinformatic analysis using multi-omic data sets.

The ideal candidate would have laboratory experience, ideally with flow cytometry or RNA sequencing, and be keen to undertake research that has a strong clinical component.



Faculty Research Themes

Child Health

School Research Themes

Child Health in Medicine



Research Opportunities

PhD students
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department / Centre

Paediatrics

Research Node

Royal Children’s Hospital/Murdoch Childrens Research Institute

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