Unravelling the aetiology of Colonic Polyposis through multi-omic profiling

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Number of Honour Places Available
1
Department
Clinical Pathology
Supervisor Email Number Webpage
Mark Clendenning mark.clendenning@unimelb.edu.au 0385597006 Personal web page
Daniel Buchanan daniel.buchanan@unimelb.edu.au 0385597004 Personal web page

Project Details

The development of a colorectal cancer (CRC) is usually preceded by pre-cursor/pre-malignant lesion called a polyp.  There are two major types of polyp defined by histological features namely the adenomatous polyp and the serrated polyp.  Individuals who develop 10 or more polyps throughout their colon are referred to as having polyposis, which predisposes individuals to develop CRC.  Approximately 30-50% of individuals with adenomatous polyposis and the majority of individuals with Serrated Polyposis do not currently have a genetic basis identified for their disease.  This project will utilise multi-omic approaches including genomics, gene and protein expression, microbiome and DNA methylation analysis to investigate the genetic basis of colonic polyposis.  This project will develop expertise in genomics, molecular biology, histology, bioinformatic and statistical analysis.  A stipend for this project is available to the selected student.



Faculty Research Themes

Cancer

School Research Themes

Cancer in Medicine



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Clinical Pathology


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