Understanding the role of the mineralocorticoid receptor (MR) for regulating the PI3K pathway in female and male hearts.

Research Opportunity
PhD students, Masters by Research, Honours students, Master of Biomedical Science, Post Doctor Researchers
Number of Honour Places Available
1
Number of Master Places Available
1
Department / Centre
Baker Department of Cardiometabolic Health
Location
Baker Heart and Diabetes Institute
Primary Supervisor Email Number Webpage
Associate Professor Morag Young morag.young@baker.edu.au 385321111 Personal web page

Summary Class IA PI3Ks are activated by receptor tyrosine kinase receptors and are critical regulators of adaptive heart growth and cardiac protection under stress conditions. Exercise-induced cardiac enlargement provides protection against cardiovascular disease, whereas disease-induced or inappropriate cardiac enlargement leads to heart failure. These distinct forms of growth are associated with different molecular profiles (e.g. mRNAs, non-coding RNAs, and proteins), and targeting differentially regulated genes has therapeutic potential for heart failure. The mineralocorticoid receptor (MR) is a steroid hormone receptor that also has a key role in regulating cardiac function and dysfunction. The MR acts as a transcription factor to regulate gene expression and can also interact with GPCRs (EGFR, VEGFR etc) and their downstream pathways to regulate cell function. This project will investigate if MR-dependent mechanisms of cardiomyocyte function are regulated in mice in which expression of PI3K is reduced, and conversely, whether PI3K pathways are altered in mice lacking the MR In cardiomyocytes. The goal of this project is to determine how the two signalling mechanisms interact in the normal and stressed heart with the view to improve therapeutic outcomes for patients with heart failure. Techniques: RNA isolation, RT and PCR, Immunostaining, Histology, western block, immunostaining/histology, cell culture.

Project Details




Research Opportunities

PhD students, Masters by Research, Honours students, Master of Biomedical Science, Post Doctor Researchers
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department / Centre

Baker Department of Cardiometabolic Health

Research Node

Baker Heart and Diabetes Institute

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