Understanding Rab39b-Mediated Parkinson's Disease

Research Opportunity
PhD
Department
Paediatrics
Location
Royal Children’s Hospital/Murdoch Childrens Research Institute
Primary Supervisor Email Number Webpage
Associate Professor Paul Lockhart paul.lockhart@mcri.edu.au +61383416322 Personal web page
Co-supervisor Email Number Webpage
Dr Kiymet Bozaoglu kiymet.bozaoglu@mcri.edu.au Personal web page

Project Details

The recent advances in our understanding of common and disabling neurodegenerative diseases such as Parkinson and Alzheimer disease has been the result of the identification and analysis of causative mutations in families, where a genetics-based approach can be utilised to identify disease associated genes. We recently identified RAB39B as a novel gene for Parkinson's disease.
This project will characterise the gene and investigate pathogenic mechanisms underlying disease utilising molecular and cell biology techniques. Studies will utilise newly developed and unique iPSC and mouse models to perform preclinical studies to characterise the disease process and identify potential therapeutic targets.



Faculty Research Themes

Child Health

School Research Themes

Child Health in Medicine



Research Opportunities

PhD
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Paediatrics

Research Node

Royal Children’s Hospital/Murdoch Childrens Research Institute

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