Understanding pneumococcal pathogenesis

Research Opportunity
PhD students
Department / Centre
Paediatrics
Location
Royal Children’s Hospital/Murdoch Childrens Research Institute
Primary Supervisor Email Number Webpage
A/Prof Catherine Satzke catherine.satzke@mcri.edu.au Personal web page
Co-supervisor Email Number Webpage
Dr Sam Manna sam.manna@mcri.edu.au Personal web page

Summary Streptococcus pneumoniae (the pneumococcus) is the most common cause of community-acquired pneumonia and a leading killer of children world-wide. However, it is also commonly found as an asymptomatic coloniser of the upper respiratory tract (carriage). Pneumococcal carriage is an important reservoir for transmission and a precursor to disease.Your research will provide new insights into how pneumococci colonise and cause disease.

Project Details

Streptococcus pneumoniae (the pneumococcus) is the most common cause of community-acquired pneumonia and a leading killer of children world-wide. However, it is also commonly found as an asymptomatic coloniser of the upper respiratory tract (carriage). Pneumococcal carriage is an important reservoir for transmission and a precursor to disease.

In this project, you will identify novel genes and characterise their role in pneumococcal carriage and/or disease. Key approaches to this project include: genetic manipulation of pneumococcal isolates, working with in vitro and/or in vivo models such respiratory cells from patients grown as air-liquid interface and mouse models, as well as microbiological and immunological analysis of local and systemic samples. Your research will provide new insights into how pneumococci colonise and cause disease.



Faculty Research Themes

School Research Themes

Child Health in Medicine



Research Opportunities

PhD students
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department / Centre

Paediatrics

Research Node

Royal Children’s Hospital/Murdoch Childrens Research Institute

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