Understanding neurotransmitter system dysfunction in schizophrenia

Research Opportunity
Masters by Research, Honours, Master of Biomedical Science
Number of Honour Places Available
1
Department
Medicine and Radiology
Location
Florey Institute of Neuroscience & Mental Health
Supervisor Email Number Webpage
Snezana Kusljic skusljic@unimelb.edu.au
Andrea Gogos andrea.gogos@florey.edu.au

Project Details

This laboratory focuses on understanding the neural mechanisms underlying the pathophysiology of psychiatric disorders such as schizophrenia and depression. These disorders are debilitating, life-long disorders that often do not remit following treatment with current drugs. It is now recognised that the development of psychiatric disorders occurs in an individual with a genetic predisposition who encounter adverse environmental factors that instigate changes which lead to the onset of the illness. The maternal immune activation (MIA) animal model involves prenatal exposure to infection, which instigates significant inflammatory processes in the foetal brain during a period of critical development. In rodents, the evidence suggests that exposure to infection during gestation results in schizophrenia-like behaviours in adulthood. This project aims to investigate the cortical changes that have occurred in the MIA model, and how this was affected by treatment with estrogenic compounds. Using receptor binding techniques, you will measure the density of various neurotransmitter receptor systems that are implicated in these psychiatric disorders, including serotonin, dopamine and noradrenaline. Students with an interest in psychiatry, neuropsychopharmacology and molecular techniques are suited to this project.



Faculty Research Themes

Neuroscience

School Research Themes

Neuroscience & Psychiatry



Research Opportunities

Masters by Research, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Node

Florey Institute of Neuroscience & Mental Health

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