Understanding neurotransmitter system dysfunction in schizophrenia
- Research Opportunity
- Masters by Research, Honours, Master of Biomedical Science
- Number of Honour Places Available
- Medicine and Radiology
- Florey Institute of Neuroscience & Mental Health
This laboratory focuses on understanding the neural mechanisms underlying the pathophysiology of psychiatric disorders such as schizophrenia and depression. These disorders are debilitating, life-long disorders that often do not remit following treatment with current drugs. It is now recognised that the development of psychiatric disorders occurs in an individual with a genetic predisposition who encounter adverse environmental factors that instigate changes which lead to the onset of the illness. The maternal immune activation (MIA) animal model involves prenatal exposure to infection, which instigates significant inflammatory processes in the foetal brain during a period of critical development. In rodents, the evidence suggests that exposure to infection during gestation results in schizophrenia-like behaviours in adulthood. This project aims to investigate the cortical changes that have occurred in the MIA model, and how this was affected by treatment with estrogenic compounds. Using receptor binding techniques, you will measure the density of various neurotransmitter receptor systems that are implicated in these psychiatric disorders, including serotonin, dopamine and noradrenaline. Students with an interest in psychiatry, neuropsychopharmacology and molecular techniques are suited to this project.
Faculty Research Themes
School Research Themes
Masters by Research, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.
Research NodeFlorey Institute of Neuroscience & Mental Health
MDHS Research library
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