Understanding how Type 17 immunity and IL-17 cytokines regulate Type 1 diabetes

Research Opportunity
PhD, Honours, Master of Biomedical Science
Number of Honour Places Available
1
Number of Master Places Available
1
Department
Medicine and Radiology
Location
St Vincent's Institute of Medical Research
Primary Supervisor Email Number Webpage
Dr Andrew Sutherland asutherland@svi.edu.au

Summary Type 1 diabetes (T1D) is a human autoimmune disease involving the progressive destruction of the insulin producing B-cells in the pancreatic islets. A clearer understanding of the autoimmune processes will provide new opportunities for therapeutic intervention in human T1D patients. Our primary goal is to cure T1D by developing novel immune therapies.

Project Details

Type 1 diabetes (T1D) is a human autoimmune disease involving the progressive destruction of the insulin producing b-cells in the pancreatic islets. A clearer understanding of the autoimmune processes will provide new opportunities for therapeutic intervention in human T1D patients. Our primary goal is to cure T1D by developing novel immune therapies.

Recent findings in our laboratory and others indicate that type 17 immune responses and IL-17 cytokines control the development of T1D in animal models. This project is focussed on identifying the underlying immune mechanisms and testing the therapeutics effects of immune inhibitors targeted against these pathways in T1D. The project will make use both mouse and human systems including newly developed gene knockout NOD mice, novel immune inhibitors, CRISPR/Cas9 gene editing, cellular and molecular immunology techniques, pancreatic islet isolation, RNA-seq, and flow cytometry.

SVI provides $5000 Honours/PhD top-up awards for a limited number of outstanding students.



Faculty Research Themes

Infection and Immunology

School Research Themes

Cardiometabolic



Research Opportunities

PhD, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Node

St Vincent's Institute of Medical Research

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