Ubiquitin Proteasome System in Schizophrenia
- Research Opportunity
- PhD students, Masters by Research, Honours students, Master of Biomedical Science
- Number of Honour Places Available
- Number of Master Places Available
- Department / Centre
- Florey Institute of Neuroscience & Mental Health
|Professor Christos Pantelisfirstname.lastname@example.org||8344 1870||Personal web page|
|Professor Ashley Bushemail@example.com||9389 2914||Personal web page|
|Dr Carlos Opazofirstname.lastname@example.org||83444125|
Summary The ubiquitin-proteasome system (UPS) is a master regulator of neural development and the maintenance of brain structure and function. It influences neurogenesis, synaptogenesis and neurotransmission by determining the localization, interaction and turnover of scaffolding, presynaptic and postsynaptic proteins. Moreover, UPS signalling transduces epigenetic changes in neurons independent of protein degradation and as such dysfunction of components and/or substrates of this system have been linked to a broad range of brain conditions. Although links between UPS dysfunction and neurodegenerative disorders have been known for some time, only recently have similar links emerged for neurodevelopmental disorders, such as schizophrenia. We and others have found that diffeerent components of the UPS are dysregulated in schizophrenia. The project aims to investigate whether specific poly-ubiquitin changes are altered in brain samples from individuals with schizhophrenia.
Our results suggest that ubiquitinated protein formation may be abnormal in the brain of those with schizophrenia. Therefore, a derangement in protein ubiquitination may be linked to pathogenesis or neurotoxicity in schizophrenia. Further studies of the UPS components are warranted in schizophrenia to better understand how this pathway is involved in this brain disorder. Post mortem human brain samples from the orbital frontal cortex will be homogenized and centrifuged to collect protein supernantants. Levels of poly-lysine-48 and poly-lysine-63 ubiquitin chains will be detected by Western blot.
Faculty Research Themes
School Research Themes
PhD students, Masters by Research, Honours students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.
Department / Centre
Research NodeFlorey Institute of Neuroscience & Mental Health
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