Ubiquitin Proteasome System in Schizophrenia

Research Opportunity
PhD students, Masters by Research, Honours students, Master of Biomedical Science
Number of Honour Places Available
2
Number of Master Places Available
1
Department / Centre
Psychiatry
Location
Florey Institute of Neuroscience & Mental Health
Primary Supervisor Email Number Webpage
Professor Christos Pantelis cpant@unimelb.edu.au 8344 1870 Personal web page
Co-supervisor Email Number Webpage
Professor Ashley Bush ashley.bush@florey.edu.au 9389 2914 Personal web page
Dr Carlos Opazo carlos.opazo@florey.edu.au 83444125

Summary The ubiquitin-proteasome system (UPS) is a master regulator of neural development and the maintenance of brain structure and function. It influences neurogenesis, synaptogenesis and neurotransmission by determining the localization, interaction and turnover of scaffolding, presynaptic and postsynaptic proteins. Moreover, UPS signalling transduces epigenetic changes in neurons independent of protein degradation and as such dysfunction of components and/or substrates of this system have been linked to a broad range of brain conditions. Although links between UPS dysfunction and neurodegenerative disorders have been known for some time, only recently have similar links emerged for neurodevelopmental disorders, such as schizophrenia. We and others have found that diffeerent components of the UPS are dysregulated in schizophrenia. The project aims to investigate whether specific poly-ubiquitin changes are altered in brain samples from individuals with schizhophrenia.

Project Details

Our results suggest that ubiquitinated protein formation may be abnormal in the brain of those with schizophrenia. Therefore, a derangement in protein ubiquitination may be linked to pathogenesis or neurotoxicity in schizophrenia. Further studies of the UPS components are warranted in schizophrenia to better understand how this pathway is involved in this brain disorder. Post mortem human brain samples from the orbital frontal cortex will be homogenized and centrifuged to collect protein supernantants. Levels of poly-lysine-48 and poly-lysine-63 ubiquitin chains will be detected by Western blot.



Faculty Research Themes

School Research Themes

Neuroscience & Psychiatry



Research Opportunities

PhD students, Masters by Research, Honours students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department / Centre

Psychiatry

Research Node

Florey Institute of Neuroscience & Mental Health

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