Type I interferon regulation of macrophage metabolism and activation
- Research Opportunity
- Number of Honour Places Available
- Medicine and Radiology
- Royal Melbourne Hospital
|Dr Andrew Fleetwoodemail@example.com||03 8344 3299||Personal web page|
Summary This project will explore how metabolic pathways shape macrophage function and inflammatory phenotype.
Project description: Macrophages can adopt a wide range of phenotypes from anti-inflammatory and wound healing to pro-inflammatory and tumouricidal. This ability to polarise their phenotype is supported by profound changes to cellular metabolic pathways. A major regulator of cellular metabolism is type I interferon (e.g. interferon-β). This project will explore the impact of interferon-β on macrophage metabolism and whether its ability to alter particular metabolic pathways is linked to its role in governing macrophage function and inflammatory phenotype.
Techniques: You will acquire a wide-range of skills in cell biology and molecular biology including primary human and mouse macrophage culture, ELISA assays, metabolic readouts, enzymatic assays, flow cytometry, Western blotting, Real‐Time PCR.
Faculty Research Themes
School Research Themes
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.
Research Group / Unit / Centre
Research NodeRoyal Melbourne Hospital
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