Type I interferon regulation of macrophage metabolism and activation

Research Opportunity
Honours
Number of Honour Places Available
1
Department
Medicine and Radiology
Location
Royal Melbourne Hospital
Primary Supervisor Email Number Webpage
Dr Andrew Fleetwood andrew.fleetwood@unimelb.edu.au 0383443299 Personal web page

Project Details

Macrophages can adopt a wide range of phenotypes from anti-inflammatory and wound healing to pro-inflammatory and tumouricidal. This ability to polarise their phenotype is supported by profound changes to cellular metabolic pathways. A major regulator of cellular metabolism is type I interferon (e.g. interferon-β). This project will explore the impact of interferon-β on macrophage metabolism and whether its ability to alter particular metabolic pathways is linked to its role in governing macrophage function and inflammatory phenotype.

Techniques: You will acquire a wide-range of skills in cell biology and molecular biology including primary human and mouse macrophage culture, ELISA assays, metabolic readouts, enzymatic assays, flow cytometry, Western blotting, Real‐Time PCR.



Faculty Research Themes

Infection and Immunology

School Research Themes

Musculoskeletal



Research Opportunities

Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Node

Royal Melbourne Hospital

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