Treatment outcome in older lung cancer patients: does the biological age predict it?

Research Opportunity
PhD, Masters by Research, Honours
Number of Honour Places Available
2
Number of Master Places Available
1
Department
Medicine and Radiology
Location
Royal Melbourne Hospital
Primary Supervisor Email Number Webpage
Prof. Andrea Maier andrea.maier@mh.org.au 0418737011 Personal web page
Co-supervisor Email Number Webpage
Dr. Claire Maddison Claire.Maddison@mh.org.au 0418737011

Summary We will determine the biological age of older lung cancer patients and test if the biological age can predict treatment outcome.

Project Details

The majority of cancers occur in patients over the age of 65 years. There is now widespread understanding that older patients are heterogeneous in terms of their physical, biological and social functioning, and that the biological age is predicting cancer treatment related outcome, such as toxicity and mortality. We hypothesize that physical, cognitive and biological markers can give a biological age and that the biological age is predictive for treatment outcome.

The project is embedded in the ongoing, worldwide first RCT examining the utility of CGA and associated interventions in patients aged 65 years or older with a new diagnosis of non-small cell lung cancer. Patients are assessed at baseline and followed up at 3, 6 and 12 months. Novel cognitive, physical and biological markers (e.g. senescence markers) will be tested and related to the clinical phenotype and outcome of the patients. A biological age score will be created. This research will eventually help predicting outcome of cancer patients and personalizing cancer treatment.



Faculty Research Themes

Cancer

School Research Themes

Cancer in Medicine, Cardiometabolic , Musculoskeletal , Ageing



Research Opportunities

PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Group / Unit / Centre

@AgeMelbourne

Research Node

Royal Melbourne Hospital

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