Treatment outcome in older lung cancer patients: does the biological age predict it?
- Research Opportunity
- PhD, Masters by Research, Honours
- Number of Honour Places Available
- Number of Master Places Available
- Medicine and Radiology
- Royal Melbourne Hospital
|Prof. Andrea Maieremail@example.com||0418737011||Personal web page|
|Dr. Claire Maddison||Claire.Maddison@mh.org.au||0418737011|
Summary We will determine the biological age of older lung cancer patients and test if the biological age can predict treatment outcome.
The majority of cancers occur in patients over the age of 65 years. There is now widespread understanding that older patients are heterogeneous in terms of their physical, biological and social functioning, and that the biological age is predicting cancer treatment related outcome, such as toxicity and mortality. We hypothesize that physical, cognitive and biological markers can give a biological age and that the biological age is predictive for treatment outcome.
The project is embedded in the ongoing, worldwide first RCT examining the utility of CGA and associated interventions in patients aged 65 years or older with a new diagnosis of non-small cell lung cancer. Patients are assessed at baseline and followed up at 3, 6 and 12 months. Novel cognitive, physical and biological markers (e.g. senescence markers) will be tested and related to the clinical phenotype and outcome of the patients. A biological age score will be created. This research will eventually help predicting outcome of cancer patients and personalizing cancer treatment.
Faculty Research Themes
School Research Themes
PhD, Masters by Research, Honours
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