The role of the non-muscle myosin component Myl9 in embryonic development and haematopoietic stem cell function

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Number of Honour Places Available
1
Number of Master Places Available
1
Department
Medicine and Radiology
Location
St Vincent's Institute of Medical Research
Primary Supervisor Email Number Webpage
A/Prof Mark Chong mchong@svi.edu.au Personal web page

Summary Previous studies from our laboratory discovered Myl9 as a novel regulator of haematopoietic stem cell (HSC) function. Dysregulated Myl9 expression causes an condition in mice similar to the myelodysplastic syndrome, which a pre-leukaemic pathology characterised by an inability of HSCs to continually replenish the cells of the immune system. We recently generated a Myl9 knockout mouse model and discovered that it is also critical for late embryonic development, with most animals dying before birth.

Project Details

Previous studies from our laboratory discovered Myl9 as a novel regulator of haematopoietic stem cell (HSC) function. Dysregulated Myl9 expression causes an condition in mice similar to the myelodysplastic syndrome, which a pre-leukaemic pathology characterised by an inability of HSCs to continually replenish the cells of the immune system. We recently generated a Myl9 knockout mouse model and discovered that it is also critical for late embryonic development, with most animals dying before birth. While is clear that Myl9 has essential roles in haematopoiesis and embryonic development, its molecular mechanism of action remains unknown. Sequence similarity to other non-muscle myosin proteins suggests that Myl9 should function in that pathway, but this have yet to be proven. Thus, the goal of this project is to determine the molecular function of Myl9 and how it regulates haematopoiesis and development.



Faculty Research Themes

Infection and Immunology

School Research Themes



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Node

St Vincent's Institute of Medical Research

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