The role of NMDA NR2B signalling in fear memory erasure in juvenile rats
- Research Opportunity
- PhD, Masters by Research, Master of Biomedical Science
- Number of Honour Places Available
- Medicine and Radiology
- Florey Institute of Neuroscience & Mental Health
|Jee Hyun Kimemail@example.com||0390356623||Personal web page|
We have hypothesized that extinction erases fear memories in juvenile rodents because extinction at this age may rely on plasticity solely within the amygdala due to the immature neural circuitry. Consistent with this idea, others have also hypothesized that the amygdala is capable of extreme plasticity at 2 weeks of age due to the high number of NR2B subunits. Although we have demonstrated that the non-selective NMDAR antagonist MK-801 injected systemically prior to extinction does not disrupt extinction consolidation in juvenile rats, MK-801 shows similar affinity to NR1/NR2A and NR1/NR2B multimers. Therefore, it remains to be answered whether extinction does involve NR1/NR2B multimers in juvenile rodents, but the relative abundance of them provides protection against the effects of MK- 801 at this age. Discovering NR2B involvement in extinction in juvenile rats will add to emerging evidence that extinction at this age shares some similarities with adult extinction.
Faculty Research Themes
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PhD, Masters by Research, Master of Biomedical Science
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Research NodeFlorey Institute of Neuroscience & Mental Health
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