The role of NMDA NR2B signalling in fear memory erasure in juvenile rats

Research Opportunity
PhD, Masters by Research, Master of Biomedical Science
Number of Honour Places Available
1
Department
Medicine and Radiology
Location
Florey Institute of Neuroscience & Mental Health
Primary Supervisor Email Number Webpage
Associate Professor Jee Hyun Kim jee.kim@florey.edu.au 0390356623 Personal web page

Project Details

We have hypothesized that extinction erases fear memories in juvenile rodents because extinction at this age may rely on plasticity solely within the amygdala due to the immature neural circuitry. Consistent with this idea, others have also hypothesized that the amygdala is capable of extreme plasticity at 2 weeks of age due to the high number of NR2B subunits. Although we have demonstrated that the non-selective NMDAR antagonist MK-801 injected systemically prior to extinction does not disrupt extinction consolidation in juvenile rats, MK-801 shows similar affinity to NR1/NR2A and NR1/NR2B multimers. Therefore, it remains to be answered whether extinction does involve NR1/NR2B multimers in juvenile rodents, but the relative abundance of them provides protection against the effects of MK- 801 at this age. Discovering NR2B involvement in extinction in juvenile rats will add to emerging evidence that extinction at this age shares some similarities with adult extinction.



Faculty Research Themes

Neuroscience

School Research Themes

Neuroscience & Psychiatry



Research Opportunities

PhD, Masters by Research, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Node

Florey Institute of Neuroscience & Mental Health

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