The role of microglial cells in epilepsy

Research Opportunity
PhD students, Masters by Research, Honours students, Master of Biomedical Science
Number of Honour Places Available
1
Number of Master Places Available
1
Department / Centre
Medicine and Radiology
Location
Royal Melbourne Hospital
Primary Supervisor Email Number Webpage
A/Prof Nigel Jones nigel.jones@monash.edu Personal web page
Co-supervisor Email Number Webpage
Dr Idrish Ali idrish.ali@monash.edu

Summary Epilepsy is a brain disease which has a complex pathophysiology. This project will examine the role of microglial cells in the development of epilepsy using a mouse model.

Project Details

Brain inflammation appears to play a critical role in the pathogenesis of epilepsy. A major cell type involved in inflammatory cascades are the microglial cells – brain-resident immune cells that become activated after epileptogenic brain injuries. Despite years of research in this area, a clear role of microglia in epilepsy development has not been established. This is partly due to the dynamic nature in which these cells get activated. The function of these cells can oscillate between different phenotypes that are associated with the release of either pro- or anti-inflammatory mediators. Therefore, depending on the stage after initial epileptogenic brain injury, their activation may promote brain repair processes or conversely accelerate the epilepsy development. This project will utilise animal models to identify the role of microglia at different stages of epilepsy development. This will be achieved by pharmacologically eliminating microglia at different timepoints following induction of epilepsy, and evaluate the relevant epilepsy outcomes by electrophysiological, molecular, immunofluorescence imaging and techniques.



Faculty Research Themes

Neuroscience

School Research Themes

Neuroscience & Psychiatry



Research Opportunities

PhD students, Masters by Research, Honours students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department / Centre

Medicine and Radiology

Research Node

Royal Melbourne Hospital

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