The role of EGFR Signaling in Glioblastoma Progression and Resistance to Current Therapies

Research Opportunity
Masters by Research, Honours
Number of Honour Places Available
1
Department
Surgery
Location
Royal Melbourne Hospital
Group Leader Email Number Webpage
Dr Rodney Luwor rluwor@unimelb.edu.au 83443027 Personal web page

Project Details

The Epidermal Growth Factor Receptor (EGFR) plays crucial roles in many physiological processes. However, in cancers including glioblastoma, the EGFR is often amplified, over-expressed and/or mutated leading to enhanced downstream signaling and pro-tumourigenic outcomes. Therefore, understanding how EGFR is regulated or controlled within the cell is pivotal for cancer biology and may allow greater scope for therapeutic intervention into EGFR-driven tumourigenesis. In addition, several groups including ours have demonstrated that tumour cells employ an EGFR-dependent mechanism to resist currently used therapeutics, leading to lack of efficacy and poor clinical outcomes.

Our research program explores many aspects of EGFR signaling outlined above. Our Honours/Masters program offers students a choice of projects within our EGFR signalling research. The student’s project may include (but is not restricted to):

1. Exploring the role of a mutant EGFR (EGFRvIII) that is prevalent in glioblastoma in mediating tumour proliferation, progression, migration and invasion.

2. Exploring the role of EGFR signaling in tumour resistance to current standard and/or targeted therapies.

3. Targeting EGFR as a potential therapeutic strategy for cancer treatment.

Furthermore, this project has the scope to evolve into a PhD project pending the ability of the incumbent student.

Skills acquisition: Cell biology techniques including Cell transfections, western blotting, immunofluorescence staining and confocal microscopy, luciferase reporter assays, RT-PCR and potentially animal handling and injecting.



Faculty Research Themes

Cancer

School Research Themes

Cancer in Medicine



Research Opportunities

Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Surgery

Research Node

Royal Melbourne Hospital

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