The role of a novel GM-CSF-CCL17 pathway in osteoarthritis
- Research Opportunity
- PhD, Masters by Research, Honours, Master of Biomedical Science
- Number of Honour Places Available
- Medicine and Radiology
- Royal Melbourne Hospital
|A/Prof Andrew Cookemail@example.com||8344 3290||Personal web page|
|Dr Ming-Chin Leefirstname.lastname@example.org||8344 3292||Personal web page|
Osteoarthritis (OA) is the most common form of arthritis, for which there are no adequate therapies. We have identified a pathway involving the inflammatory mediator, granulocyte macrophage-colony stimulating factor (GM-CSF), the transcription factor interferon regulatory factor 4 (IRF4) and the chemokine, CCL17, which appears to be important for the development of OA and its associated pain in animal models
In this project you will use models of OA to investigate how this pathway is active in pain and disease development and whether blockade of the pathway at different stages is able to halt disease progression. A variety of skills will be acquired including induction of animal models, histology, gene expression analysis and FACS analysis.
School Research Themes
PhD, Masters by Research, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.
Research Group / Unit / Centre
Research NodeRoyal Melbourne Hospital
MDHS Research library
Explore by researcher, school, project or topic.