The role of a novel GM-CSF-CCL17 pathway in osteoarthritis

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Number of Honour Places Available
1
Department
Medicine and Radiology
Location
Royal Melbourne Hospital
Supervisor Email Number Webpage
Ming-Chin Lee ming-chin.lee@unimelb.edu.au 8344 3292 Personal web page
Andrew Cook adcook@unimelb.edu.au 8344 3290 Personal web page

Project Details

Osteoarthritis (OA) is the most common form of arthritis, for which there are no adequate therapies. We have identified a pathway involving the inflammatory mediator, granulocyte macrophage-colony stimulating factor (GM-CSF), the transcription factor interferon regulatory factor 4 (IRF4) and the chemokine, CCL17, which appears to be important for the development of OA and its associated pain in animal models

In this project you will use models of OA to investigate how this pathway is active in pain and disease development and whether blockade of the pathway at different stages is able to halt disease progression. A variety of  skills will be acquired including induction of animal models, histology, gene expression analysis and FACS analysis.


School Research Themes

Musculoskeletal



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Group / Unit / Centre

Hamilton Laboratory

Research Node

Royal Melbourne Hospital

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