The effect of epilepsy on bone
- Research Opportunity
- Number of Honour Places Available
- Medicine and Radiology
- Royal Melbourne Hospital
|Dr Rhys Bradyfirstname.lastname@example.org|
|A/Prof Sandy Shultzemail@example.com|
It is widely accepted that epilepsy patients often have reduced bone mineral density and are at an increased risk of bone fracture, which is associated with significant morbidity and reduced quality of life. The mechanisms by which various forms of epilepsy may cause a reduction in bone mineral density are incompletely understood. This is due to the difficulties of studying these conditions in humans. Animal models allow for the control of many of these limitations. Therefore, in this study we will use well established rodent models of genetic and acquired epilepsy to determine the effect various forms of epilepsy have on bone.
The majority of epilepsy patients are treated with antiepileptic drugs, hence it is also important to consider the possible effect of these therapies on bone. Therefore, here we aim to determine the effect of novel antiepileptic therapies Z944 and sodium selenate on bone. This innovative and clinically relevant project will enhance the understanding of the relationship between epilepsy and bone metabolism and the effects of highly promising and novel antiepileptic drugs on bone.
Faculty Research Themes
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