The effect of epilepsy on bone

Research Opportunity
Number of Honour Places Available
Medicine and Radiology
Royal Melbourne Hospital
Primary Supervisor Email Number Webpage
Dr Rhys Brady
Co-supervisor Email Number Webpage
A/Prof Sandy Shultz

Project Details

It is widely accepted that epilepsy patients often have reduced bone mineral density and are at an increased risk of bone fracture, which is associated with significant morbidity and reduced quality of life. The mechanisms by which various forms of epilepsy may cause a reduction in bone mineral density are incompletely understood. This is due to the difficulties of studying these conditions in humans. Animal models allow for the control of many of these limitations. Therefore, in this study we will use well established rodent models of genetic and acquired epilepsy to determine the effect various forms of epilepsy have on bone.

The majority of epilepsy patients are treated with antiepileptic drugs, hence it is also important to consider the possible effect of these therapies on bone. Therefore, here we aim to determine the effect of novel antiepileptic therapies Z944 and sodium selenate on bone. This innovative and clinically relevant project will enhance the understanding of the relationship between epilepsy and bone metabolism and the effects of highly promising and novel antiepileptic drugs on bone.

Faculty Research Themes


School Research Themes

Neuroscience & Psychiatry, Musculoskeletal

Research Opportunities

Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.


Medicine and Radiology

Research Node

Royal Melbourne Hospital

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