The central amygdala endogenous opioid system in salt appetite

Research Opportunity
PhD, Masters by Research, Honours
Number of Honour Places Available
1
Department
Medicine and Radiology
Location
Florey Institute of Neuroscience & Mental Health
Supervisor Email Number Webpage
Sarah Ch'ng sarah.chng@florey.edu.au
Andrew Lawrence Andrew.Lawrence@florey.edu.au 90356692 Personal web page

Project Details

Project description: Due to the essential biological role of sodium, terrestrial animals have evolved a behaviour known as “salt appetite”, whereby dietary sodium (typically in the form of NaCl) is readily sought. At a behavioural level, salt appetite can be parsed into two components: the motivation to consume salt (how much it is “wanted”), and the palatability of salt (how much it is “liked”). Under conditions of salt depletion, there is an increase in the motivation to consume salt and the palatability of salt. We have identified that mu opioid receptor (MOR) signalling in the central amygdala is critical for increased salt appetite in salt-depleted mice. However, it is unclear whether central amygdala MOR signalling mediates the motivation to consume salt and/or its palatability. The aim of this project is to elucidate the involvement of central amygdala MOR signalling in the motivation to consume salt. We will examine the effects of administering naloxonazine (a selective antagonist of the MOR) into the central amygdala on operant self-administration of salt in mice. This will enable us to quantify the contribution of central amygdala MOR signalling to the motivation to consume salt during gratification of salt appetite.



Faculty Research Themes

Neuroscience

School Research Themes

Neuroscience & Psychiatry



Research Opportunities

PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Node

Florey Institute of Neuroscience & Mental Health

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