The blood pressure drop makes you fall

Research Opportunity
PhD, Masters by Research, Honours
Number of Honour Places Available
1
Number of Master Places Available
1
Department
Medicine and Radiology
Location
Royal Melbourne Hospital
Primary Supervisor Email Number Webpage
Prof. Andrea Maier andrea.maier@mh.org.au 0418737011 Personal web page

Summary (Initial) orthostatic hypotension ((i)OH) is highly prevalent in older adults, especially in those with one or more chronic diseases. This project will focus on determinants and outcomes related to (i)OH in patients in rehabilitation and visiting the outpatient clinics to guide future pharmacological intervention studies.

Project Details

(Initial) orthostatic hypotension ((i)OH) is highly prevalent in older adults, especially in those with one or more chronic diseases. iOH is defined as a blood pressure decrease(BP) of 40 mmHg systolic blood pressure (SBP) and/or 20 mmHg diastolic blood pressure (DBP) within 15 seconds after standing up, whereas OH is classically defined as a drop in BP of at least 20 mmHg of SBP and/or 10 mmHg of DBP at 1 and 3 minutes after standing up. iOH has been shown to be most predictive for balance impairment, increased self-reported impaired standing balance, falls and cognitive impairment in older adults. While OH diagnostics are occasionally performed in clinical practice using a sphygmomanometer, continuously measured blood pressure measurements using beat to beat analyses has not entered routine geriatric care yet.

Aim project 1: Define the determinates of iOH and OH and consequences of iOH and OH in geriatric outpatients using an existing databases and ongoing cohort study.

Aim project 2: Analysis of effectiveness of pharmacological interventions to counteract iOH and OH.

Relevant literature:

  • https://www.ncbi.nlm.nih.gov/pubmed/30608209
  • https://www.ncbi.nlm.nih.gov/pubmed/30771059
  • https://www.ncbi.nlm.nih.gov/pubmed/30583909
  • https://www.ncbi.nlm.nih.gov/pubmed/30825549


Faculty Research Themes

Neuroscience

School Research Themes

Neuroscience & Psychiatry, Ageing, Cardiometabolic



Research Opportunities

PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Node

Royal Melbourne Hospital

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