Targeting Pyroptosis to improve diabetic cardiovascular disease.

Research Opportunity
Honours students
Number of Honour Places Available
1
Number of Master Places Available
1
Department / Centre
Baker Department of Cardiometabolic Health
Location
Baker Heart and Diabetes Institute
Primary Supervisor Email Number Webpage
Prof Judy de Haan judy.dehaan@baker.edu.au 0411222985
Co-supervisor Email Number Webpage
Dr Arpeeta Sharma arpeeta.sharma@baker.edu.au

Summary Cardiovascular complications associated with Type 2 diabetes (T2D) lead to significant morbidity and mortality, for which standard treatment options are insufficient to halt or reduce this clinical burden. Recent clinical evidence from the successful CANTOS trial suggests that targeting the cytokine IL-1b lessens inflammation and reduces the burden of cardiovascular disease. IL-1b is matured on the NLRP3-inflammasome along with IL-18 and GasderminD, the pyroptosis (a specific form of cell death) regulating protein. Pyroptosis and release of detrimental cytokines is hypothesized to propagate cardiovascular disease. This proposal will investigate the role of pyroptosis in mediating diabetes-driven cardiomyopathy.

Project Details

This project aims to investigate whether targeting pyroptosis in diabetic cardiovascular disease will lessen inflammation and diabetes-associated cardiac injury.

Key Scientific Skills: The student will receive training in  vivo mouse models of diabetes, cell culture, immunohistochemistry, histology, real time PCR and Western Blotting.



Faculty Research Themes

School Research Themes

Cardiometabolic



Research Opportunities

Honours students
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department / Centre

Baker Department of Cardiometabolic Health

Research Node

Baker Heart and Diabetes Institute

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