Early Stages of Age-Related Macular Degeneration (Imaging Biomarkers for Treatment Discovery)

Research Opportunity
PhD students
Department / Centre
Surgery
Location
Surgery, Ophthalmology, Royal Victorian Eye and Ear Hospital
Primary Supervisor Email Number Webpage
A/Prof Zhichao Wu wu.z@unimelb.edu.au +61 3 9929 8396
Co-supervisor Email Number Webpage
Prof Robyn Guymer AM rh.guymer@unimelb.edu.au

Summary A major impediment to the discovery of preventative interventions in the early stages of age-related macular degeneration (AMD) is the need for large and lengthy clinical trials to assess their efficacy. This is due to our current inability to identify those at high risk of progression to target for such trials, and the lack of effective disease biomarkers to act as earlier indicators of treatment efficacy. There is thus an urgent need for such biomarkers to pave the way for therapeutic innovation to prevent irreversible vision loss.

Project Details

A major impediment to the discovery of preventative interventions in the early stages of age-related macular degeneration (AMD) is the need for large and lengthy clinical trials to assess their efficacy. This is due to our current inability to identify those at high risk of progression to target for such trials, and the lack of effective disease biomarkers to act as earlier indicators of treatment efficacy. There is thus an urgent need for such biomarkers to pave the way for therapeutic innovation to prevent irreversible vision loss.

Modern retinal imaging techniques now provide an unprecedented level of detail about the changes occurring in the early stages of AMD in vivo, providing new opportunities to identify the urgently needed disease biomarkers. Projects are thus available to address this overarching aim, evaluating novel imaging-based biomarkers in the early stages of AMD. These projects can be extended to include analyses of into phenotype-genotype associations, or to take a focus on training AI models to automatically identify key biomarkers for implementation in clinical trials.



Faculty Research Themes

Neuroscience

School Research Themes

Neuroscience & Psychiatry, Ageing



Research Opportunities

PhD students
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department / Centre

Surgery

Research Node

Surgery, Ophthalmology, Royal Victorian Eye and Ear Hospital

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