Structure-based drug design of selective Drp1 inhibitors

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Number of Honour Places Available
1
Number of Master Places Available
1
Department
Medicine and Radiology
Location
St Vincent's Institute of Medical Research
Primary Supervisor Email Number Webpage
Dr Jessica Holien jholien@svi.edu.au
Co-supervisor Email Number Webpage
Dr Belinda Abbott b.abbott@latrobe.edu.au
Dr Christopher Langendorf clangendorf@svi.edu.au
Dr Shiang Yong (Max) Lim mlim@svi.edu.au

Summary The mitochondrial protein dynamin-related protein (Drp1) has been implicated in the development of a number of diseases, including; cancer, heart disease and Alzheimer’s disease. To date, no direct small molecule drugs of human Drp1 have been identified. This project will use rational drug discovery techniques to develop these small molecule drugs.

Project Details

The mitochondrial protein dynamin-related protein (Drp1) has been implicated in the development of a number of diseases, including; cancer, heart disease and Alzheimer’s disease. To date, no direct small molecule drugs of human Drp1 have been identified. This project will use rational drug discovery techniques to develop these small molecule drugs. Namely, this project will design these drugs using in silico techniques, utilise medicinal chemistry to synthesise the drugs, and then test these drugs using both in vitro and cellular assays. Furthermore, X-ray crystallography and site-directed mutagenesis will be conducted to get a complete understanding of how these drugs are interacting. Ultimately, this project will provide important research tools to reveal the specific role of Drp1 in disease and as potential leads for drug development.


School Research Themes

Cancer in Medicine, Neuroscience & Psychiatry, Cardiometabolic



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Node

St Vincent's Institute of Medical Research

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