Structural biology of proteins involved in mental illnesses

Research Opportunity
PhD students, Masters by Research
Department / Centre
Medicine
Location
St Vincent's Institute of Medical Research
Primary Supervisor Email Number Webpage
Prof Michael Parker mparker@svi.edu.au Personal web page

Summary Alzheimer’s disease (AD) is the fourth biggest killer in developed countries. Amyloid precursor protein (APP) plays a central role in the development of AD, through generation of the toxic Abeta peptide by proteolytic breakdown of APP. Here we will use X-ray crystallography at the Australian Synchrotron to determine the 3D atomic structures of Abeta bound to therapeutic antibodies currently in clinical trials in order to understand how these molecules recognise Abeta. We use this information to engineer more potent antibodies as treatments for AD.

Project Details

Alzheimer’s disease (AD) is the fourth biggest killer in developed countries. Amyloid precursor protein (APP) plays a central role in the development of AD, through generation of the toxic Abeta peptide by proteolytic breakdown of APP. Here we will use X-ray crystallography at the Australian Synchrotron to determine the 3D atomic structures of Abeta bound to therapeutic antibodies currently in clinical trials in order to understand how these molecules recognise Abeta. We have also developed novel diabodies which can target Abeta for elimination. Structural biology will guide engineering of more potent antibodies and diabodies as treatments for AD.



Faculty Research Themes

Neuroscience

School Research Themes

Neuroscience & Psychiatry



Research Opportunities

PhD students, Masters by Research
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department / Centre

Medicine

Research Group / Unit / Centre

Structural biology unit

Research Node

St Vincent's Institute of Medical Research

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