Stroke Biomarker Study; Role of Infections and Ischemic Stroke

Research Opportunity
PhD, Masters by Research
Department
Medicine and Radiology
Location
Western Health
Primary Supervisor Email Number Webpage
Associate Professor Tissa Wijeratne twi@unimelb.edu.au Personal web page

Project Details

A blood biomarker of stroke can be any quantifiable entity that reflects the manifestation of a stroke related process. Most of the known biomarkers have very little practical value in stroke. The most useful application of stroke biomarkers is in areas where information from traditional clinical sources is limited.The potential use of rapidly measurable blood biomarkers to determine the cause of stroke admission would help to identify patients who need specific preventative measures such as oral anticoagulation, and thus, facilitate better and precise secondary prevention with improved patient outcome.Of particular interest, the role of infection in stroke is complex and remains incompletely understood.

Therefore, this study is aimed at examining evidence of recent acute systemic infection of any type as a stroke trigger, focusing on the relationship between acute infection with timing of acute stroke in adult stroke patients admitted to Sunshine Hospital, prospectively.100 patients with acute ischemic stroke will be recruited, whereby evidence of recent acute infections will be identified via collection of blood samples. Identification of the following organisms implicated in stroke pathogenesis will be of particular focus:Bacterial infections including Treponema pallidum, Mycobacterium tuberculosis, Chlamydia pneumonia, Helicobacter pylori, Prophyromonas gingivalis and other periodontal pathogens, and viral infections including HIV, CMV, Varicella zoster, Herpes simplex types 1 and 2, Parvovirus B 19.

Where consent is provided, spouse of patients will also be recruited into the study to identify any evidence of the same infections. We anticipate that this study will provide further understanding of the association between infections and stroke.



Faculty Research Themes

Neuroscience

School Research Themes

Neuroscience & Psychiatry



Research Opportunities

PhD, Masters by Research
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Node

Western Health

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