Sodium Selenate as a Disease Modifying Treatment for Probable Behavioural Variant Front-temporal Dementia

Research Opportunity
PhD, Masters by Research, Honours, Post Doctor Research
Number of Honour Places Available
2
Number of Master Places Available
1
Department
Medicine and Radiology
Location
Royal Melbourne Hospital
Primary Supervisor Email Number Webpage
Professor Terence O'Brien obrientj@unimelb.edu.au 9903 0855 Personal web page
Co-supervisor Email Number Webpage
Dr Charles Malpas charles.malpas@unimelb.edu.au Personal web page
Dr. Lucy Vivash Vivash Lucy (Lucy.Vivash@mh.org.au)

Summary Sodium Selenate as a Disease Modifying Treatment for Probable Behavioural Variant Front-temporal Dementia

Project Details

Frontotemporal dementia (FTD) is generally due to abnormalities either in a protein called tau (45%) or a protein called TDP-43 (45%). In both types of FTD the protein aggregates into ‘clumps’ that block brain cell function. There are currently no treatments for either type of FTD. Our group has successfully run several research trials using a drug called sodium selenate that prevents the aggregation of tau in brain cells. We have shown that sodium selenate is safe in humans and that it has measurable benefits in Alzheimers disease (a different type of dementia to FTD). This study is an early phase study in which participants with FTD receive sodium selenate and are followed over 12 months. During this period standardised measurements of safety, cognition and neuroimaging (MRI, PET) will be undertaken.



Faculty Research Themes

Neuroscience



Research Opportunities

PhD, Masters by Research, Honours, Post Doctor Research
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Group / Unit / Centre

Epilepsy and Neuropharmacology

Research Node

Royal Melbourne Hospital

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