Sex based differences in response to total joint replacement for osteoarthritis of the lower limb

Research Opportunity
Honours
Number of Honour Places Available
1
Department
Surgery
Location
St Vincent's Hospital
Primary Supervisor Email Number Webpage
A/Prof Michelle Dowsey mmdowsey@unimelb.edu.au Personal web page
Co-supervisor Email Number Webpage
Prof Peter Choong sarcoma@bigpond.net.au Personal web page

Summary Sex based differences in response to TJR exist but are often ignored and therefore poorly understood. The Department of Surgery at St. Vincent’s houses the St. Vincent's Melbourne Arthroplasty (SMART) Outcomes Registry. SMART is a unique clinical registry that holds outcome data in more than 11,000 patients who have undergone lower limb joint replacement. Over 100,000 patient pain, function and quality of life surveys are recorded in the Registry. An opportunity to undertake a detailed examination of the sex-based differences in morbidity and mortality outcomes of patients undergoing TJR is available. This longitudinal cohort study has the potential to inform future trial design and targeted treatment to ensure equitable and optimal outcomes for all those considering joint replacement surgery.

Project Details

Total joint replacement (TJR) surgery is recommended to ameliorate pain, reduce disability and improve quality of life for people with advanced osteoarthritis who no longer respond to conservative management. In 2018 >110,000 TJRs were performed in Australia at a cost of >$5 billion dollars. While a highly effective procedure for many, 12-20% of patients report ongoing significant pain and disability up to 5 years post-TJR.  Differentiating who will derive a meaningful improvement from TJR from others remain a challenge for Orthopaedic Surgeons. Sex based differences in response to TJR exist but are often ignored and therefore poorly understood. The Department of Surgery at St. Vincent’s houses the St. Vincent's Melbourne Arthroplasty (SMART) Outcomes Registry. SMART is a unique clinical registry that holds outcome data in more than 11,000 patients who have undergone lower limb joint replacement.  Over 100,000 patient pain, function and quality of life surveys are recorded in the Registry. An opportunity to undertake a detailed examination of the sex-based differences in morbidity and mortality outcomes of patients undergoing TJR is available.  This longitudinal cohort study has the potential to inform future trial design and targeted treatment to ensure equitable and optimal outcomes for all those considering joint replacement surgery.


School Research Themes

Musculoskeletal



Research Opportunities

Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Surgery

Research Node

St Vincent's Hospital

MDHS Research library
Explore by researcher, school, project or topic.