Senescence as a measure of morbidity
- Research Opportunity
- Number of Honour Places Available
- Medicine and Radiology
- Royal Melbourne Hospital
|Dr Camilla Tuttlefirstname.lastname@example.org||83443253||Personal web page|
|Professor Andrea Maieremail@example.com||Personal web page|
However, all current human senescent research has focused on how senescence can influence a specific disease pathology. Yet, the geroscience hypothesis asserts that the ageing process is the underlying cause of all chronic diseases and targeting this process would attenuate multiple diseases. As such, if senescent cell accumulation is driving the ageing process a higher senescent cell load should correlate to a multimorbid phenotype. Yet, there is currently no human evidence to support this theory. The lack of human evidence is largely due to methodological issues relating to the invasive nature and practicalities of taking multiple tissue biopsies from different sites of pathology in one individual. However, a recent study investigating p16 expression in glaucoma found a positive association with the number of senescent cells and disease not only in tissue samples but also in blood samples from the same participants. As such, this project aims to determine if the senescent load of blood within an individual correlates with severity of disease and morbidity. Findings from this project will help determine if senescence can be used as a clinical indicator for health status.
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