Senescence as a measure of morbidity

Research Opportunity
Masters by Research, Honours
Number of Honour Places Available
1
Number of Master Places Available
1
Department
Medicine and Radiology
Location
Royal Melbourne Hospital
Primary Supervisor Email Number Webpage
Dr Camilla Tuttle camilla.tuttle@unimelb.edu.au 03 8344 3253 Personal web page
Co-supervisor Email Number Webpage
Prof Andrea Maier andrea.maier@mh.org.au 03 9342 2635 Personal web page

Summary Ageing is the biggest underlying risk for the development of all chronic diseases. Within the last decade cellular senescence (permanent cell cycle arrest) has been identified as a central component of ageing. This project aims to determine if the senescent load of blood within an individual is associated with morbidity.

Project Details

Ageing is the biggest underlying risk for the development of all chronic diseases. As such, Geroscientists have hypothesised, that therapeutically targeting the ageing process will delay the onset of multiple chronic diseases; increasing an individual’s healthspan. Determining the underlying molecular causes of ageing is paramount, to developing treatments that target multiple diseases through manipulation of the ageing process. Within the last decade cellular senescence (permanent cell cycle arrest) has been identified as a central component of ageing.  Current human senescent research has focused on how senescence can influence a specific disease pathology and does not consider the multimorbid patient presentation.  If senescent cell accumulation is driving the ageing process higher senescent cell numbers may be associated with a multimorbid phenotype. Yet, there is currently no human evidence to support this theory. The lack of human evidence is largely due to methodological issues relating to the invasive nature and practicalities of taking multiple tissue biopsies from different sites of pathology in one individual. However, a recent study investigating p16 expression in glaucoma found a positive association with the number of senescent cells and disease not only in tissue samples but also in blood samples from the same participants.  As such, this project aims to determine if the senescent cell numbers in blood within an individual is associated with higher morbidity.


School Research Themes

Ageing



Research Opportunities

Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Group / Unit / Centre

@AgeMelbourne

Research Node

Royal Melbourne Hospital

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