Senescence as a measure of morbidity

Research Opportunity
Honours
Number of Honour Places Available
2
Department
Medicine and Radiology
Location
Royal Melbourne Hospital
Primary Supervisor Email Number Webpage
Dr Camilla Tuttle camilla.tuttle@unimelb.edu.au 83443253 Personal web page
Co-supervisor Email Number Webpage
Professor Andrea Maier andrea.maier@unimelb.edu.au Personal web page

Project Details

However, all current human senescent research has focused on how senescence can influence a specific disease pathology. Yet, the geroscience hypothesis asserts that the ageing process is the underlying cause of all chronic diseases and targeting this process would attenuate multiple diseases. As such, if senescent cell accumulation is driving the ageing process a higher senescent cell load should correlate to a multimorbid phenotype. Yet, there is currently no human evidence to support this theory. The lack of human evidence is largely due to methodological issues relating to the invasive nature and practicalities of taking multiple tissue biopsies from different sites of pathology in one individual. However, a recent study investigating p16 expression in glaucoma found a positive association with the number of senescent cells and disease not only in tissue samples but also in blood samples from the same participants. As such, this project aims to determine if the senescent load of blood within an individual correlates with severity of disease and morbidity. Findings from this project will help determine if senescence can be used as a clinical indicator for health status.


School Research Themes

Ageing



Research Opportunities

Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Group / Unit / Centre

@AgeMelbourne

Research Node

Royal Melbourne Hospital

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