Search early diagnosis biomarkers for Alzheimer’s disease

Research Opportunity
Honours, Master of Biomedical Science
Number of Honour Places Available
1
Department
Medicine and Radiology
Location
Florey Institute of Neuroscience & Mental Health
Primary Supervisor Email Number Webpage
Dr Ben J Gu ben.gu@florey.edu.au 0390356317
Co-supervisor Email Number Webpage
Prof. James S. Wiley james.wiley@florey.edu.au 0383446386

Project Details

Alzheimer’s disease is an age-related dementia with major impact in people aged 60 or over.  Typical symptoms including memory loss and cognitive impairment but the pathogenesis is unclear and treatment options are limited. Recent evidence suggests the scavenger receptors including the P2X7 receptor may be involved in the pathogenesis of this disease. This project will study the peripheral blood cells and urine samples obtained from patients with Alzheimer’s disease or minor cognitive impairment as well as from age matched healthy controls. The scavenger receptor and function on mononuclear cells and various phenotyping and serological assays will be performed. The diagnostic and prognostic values of variables will be evaluated. This work may provide a useful biomarker for the early diagnosis and prognosis of Alzheimer’s disease, as well as the possible pathogenesis mechanism.

Techniques involved are flow cytometry, ELISA, immunochromatography and cell culture.



Faculty Research Themes

Neuroscience

School Research Themes

Neuroscience & Psychiatry, Ageing



Research Opportunities

Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Medicine and Radiology

Research Node

Florey Institute of Neuroscience & Mental Health

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