Roles of mammary adipose macrophages in breast cancer

Research Opportunity
PhD students, Masters by Research, Honours students, Master of Biomedical Science
Number of Honour Places Available
2
Number of Master Places Available
1
Department / Centre
Medicine
Location
Royal Melbourne Hospital
Primary Supervisor Email Number Webpage
Dr Adrian Achuthan aaa@unimelb.edu.au 8344 3298 Personal web page
Co-supervisor Email Number Webpage
Dr Ajithkumar Vasanthakumar ajith.vasanthakumar@unimelb.edu.au Personal web page

Summary Mammary adipose forms the large fraction of breast tumour microenvironment (TME). Macrophages, in particular tumour associated macrophages, are known to promote immune suppression to promote cancer growth. In the last decade, immune checkpoint inhibitors have revolutionised cancer therapy. However, this approach has had only limited success in breast cancers. While immune checkpoint inhibitors boost anti-tumour immune cells, immune suppression in TME could dampen this process. In this project, you will explore the role of mammary adipose macrophages and their response to immune checkpoint inhibitors.

Project Details

Project description: Mammary adipose forms the large fraction of breast tumour microenvironment (TME). Macrophages, in particular tumour associated macrophages, are known to promote immune suppression to promote cancer growth. In the last decade, immune checkpoint inhibitors have revolutionised cancer therapy. However, this approach has had only limited success in breast cancers. While immune checkpoint inhibitors boost anti-tumour immune cells, immune suppression in TME could dampen this process. In this project, you will explore the role of mammary adipose macrophages and their response to immune checkpoint inhibitors.

Techniques: You will acquire a wide-range of skills in molecular and cellular biology (cell culture, qPCR, ELISA, Western blotting), as well as animal models of breast cancer.



Faculty Research Themes

School Research Themes

Cancer in Medicine, Women's Health



Research Opportunities

PhD students, Masters by Research, Honours students, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department / Centre

Medicine

Research Node

Royal Melbourne Hospital

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