Roles of macrophages subpopulations in tumour microenvironment in gastric cancer
- Research Opportunity
- PhD students, Masters by Research
- Department / Centre
- Royal Melbourne Hospital
|Dr Adrian Achuthanemail@example.com||83443298||Personal web page|
|Professor Alex Boussioutasfirstname.lastname@example.org||8344 6252|
Summary In this project you will explore the roles of proinflammatory (e.g. IFNgamma) and anti‐inflammatory cytokines (e.g. IL‐10) driving the heterogeneity of macrophage populations. Our previous genomic experiments have provided a number of exciting candidate genes that may be involved in the effector functions of these macrophage subpopulations.
Project description: Gastric cancer (GC) is the fourth most common cancer globally and 7th in incidence in Australia. It has a poor survival rate which can be attributed to the advanced stage at diagnosis in most patients. The molecular and cellular mechanisms underlying the development of GC are not well described. Traditionally cancer research involved studying the cancer cell itself. More recently, there has been growing interest in studying the normal cells and molecules which surround the cancer cell. This tumour microenvironment consists of a variety of immune cells. Tumour‐associated macrophages (TAMs) are one of the most abundant immune components in GC. Our recent data demonstrated that the heterogeneity of macrophages within the tumour is present at both micro‐ and macro‐levels due to the gradient change of different macrophage markers, namely IRF8, CD68, CD163 and CD206. This study highlights the need for investigating the roles of macrophage subpopulations in a tissue setting, to identify potential therapeutic candidates and to understand the immune landscape of GC. In this project you will explore the roles of proinflammatory (e.g. IFNgamma) and anti‐inflammatory cytokines (e.g. IL‐10) driving the heterogeneity of macrophage populations. Our previous genomic experiments have provided a number of exciting candidate genes that may be involved in the effector functions of these macrophage subpopulations. You will be validating their expression and regulation in control and GC patient samples.
Faculty Research Themes
School Research Themes
PhD students, Masters by Research
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.
Department / Centre
Research NodeRoyal Melbourne Hospital
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