Risk and resilience in schizophrenia from the perspective of brain networks
- Research Opportunity
- Project Status
|Dr Andrew Zalesky|
|Dr Vanessa Cropleyfirstname.lastname@example.org|
Schizophrenia is a debilitating neuropsychiatric disorder ranked among the world’s top-ten leading causes of death and disability. To date, most research in schizophrenia has focused on identifying genetic, biochemical, neurobiological, and cognitive risk factors that may lead to the illness. However, there is increasing recognition for the need to identify putative factors conferring resilience to developing the disorder.
This project will use state-of-the-art neuroimaging techniques to investigate neuroimaging-based resilience endophenotypes associated with schizophrenia. Specifically, the project will investigate brain networks, which are a comprehensive description of the brain’s internal wiring. Advances in magnetic resonance imaging (MRI) have now enabled reliable mapping of an individual's white matter network or connectome. The study will investigate brain networks in patients affected with schizophrenia, their unaffected siblings and healthy comparison subjects. Resilience endophenotypes will be identified by comparing ill individuals with their unaffected family members. The student will be involved in the development and/or application of neuroimaging tools from a brain network perspective.
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