Repair of the cornea to restore vision
- Research Opportunity
- PhD, Masters by Research, Honours
- Number of Honour Places Available
- Surgery, Ophthalmology, Royal Victorian Eye and Ear Hospital
|Dr Mark Daniell|
|Prof Greg Dustingemail@example.com|
Severe burns and corneal disease leads to vascularization and ulceration of the corneal surface, which is currently treated by corneal transplants and lifelong anti-rejection drugs. Many countries in the world do not have sufficient donors to meet the increasing demand for this procedure. At CERA we work closely with chemical engineers and veterinary scientists at the University of Melbourne to develop engineered constructs to replace the damaged corneal endothelium.
The current project is to develop a source of corneal endothelium from human induced pluripotent stem cells (iPS cells) and grow these on patented hydrogel films to replace damaged endothelium. Alternatively, the reprogramming of appropriate patient cells direct to corneal endothelium will be explored. Mechanisms of adhesion and proliferation of these cells will be examined, and preclinical transplantation studies will be carried out in sheep in the veterinary facility. This project would be suitable for biomedical science students with an interest in cell biology, pharmacology or ophthalmology to work towards clinical application of this novel technique with an ophthalmologist, stem cell scientist, veterinary scientists and other cell biologists.
This project is conducted in Centre for Eye Research Australia, Corneal Research Unit.
PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.
Research NodeSurgery, Ophthalmology, Royal Victorian Eye and Ear Hospital
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