Repair of the cornea to restore vision

Research Opportunity
PhD, Masters by Research, Honours
Number of Honour Places Available
1
Department
Surgery
Location
Surgery, Ophthalmology, Royal Victorian Eye and Ear Hospital
Group Leader Email Number Webpage
Dr Mark Daniell
Primary Supervisor Email Number Webpage
Prof Greg Dusting g.dusting@unimelb.edu.au

Project Details

Severe burns and corneal disease leads to vascularization and ulceration of the corneal surface, which is currently treated by corneal transplants and lifelong anti-rejection drugs. Many countries in the world do not have sufficient donors to meet the increasing demand for this procedure. At CERA we work closely with chemical engineers and veterinary scientists at the University of Melbourne to develop engineered constructs to replace the damaged corneal endothelium.

The current project is to develop a source of corneal endothelium from human induced pluripotent stem cells (iPS cells) and grow these on patented hydrogel films to replace damaged endothelium. Alternatively, the reprogramming of appropriate patient cells direct to corneal endothelium will be explored. Mechanisms of adhesion and proliferation of these cells will be examined, and preclinical transplantation studies will be carried out in sheep in the veterinary facility. This project would be suitable for biomedical science students with an interest in cell biology, pharmacology or ophthalmology to work towards clinical application of this novel technique with an ophthalmologist, stem cell scientist, veterinary scientists and other cell biologists.

This project is conducted in Centre for Eye Research Australia, Corneal Research Unit.




Research Opportunities

PhD, Masters by Research, Honours
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Surgery

Research Node

Surgery, Ophthalmology, Royal Victorian Eye and Ear Hospital

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