Regulation of Cancer Development by Transforming Growth Factor-beta Signalling

Research Opportunity
PhD, Masters by Research, Honours, Master of Biomedical Science
Number of Honour Places Available
2
Department
Surgery
Location
Royal Melbourne Hospital
Supervisor Email Number Webpage
Hong-Jian Zhu hongjian@unimelb.edu.au 83443025 Personal web page

Project Details

Cancer Signalling Research Laboratory comprises a creative and independent research team of biomedical scientist with proven instinct and track record for identifying fundamental molecular events underlying biological function and human diseases (cancer and fibrosis). Specifically, the laboratory focuses on the transforming growth factor-b signalling regulation during early and late tumour development. Mechanistically, we are the first to establish the rotation-activation model for the receptor system and the critical role of signalling sensitivity in development and diseases. On cancer biology, we have integrated other discrete signalling pathways such as IL-6/gp130/Stat3, EGF/EGFR and Wnt/Apc with TGF-b signalling in respect to the development of cancers of stomach, head&neck and lung and colon. In addition, the lab have developed a wide range of unique molecular and cellular tools applicable both in vitro and in vivo such as single cell identification, single cell signalling and live animal imaging. Currently, we are completing the study on the dynamic regulation of TGF-b signalling during tumour invasion, circulation and metastasis as well as tumour cell plasticity, particularly regarding endothelilzation of cancer cells in tumour angiogenesis. Importantly, we are also developing totally new strategies based on our lab’s findings for the treatment of cancer. Given the majority of cancer mortality arises from metastasis and it is only a very small fraction of cancer cells being able to metastasize, our lab’s current focus is on the exciting future of the identification of single cancer cells and single cell signalling at real-time in live cells both in vitro and in vivo.

Currently, we are completing the study on the dynamic regulation of TGF-b signalling during tumour invasion, circulation and metastasis as well as tumour cell plasticity, particularly regarding endothelilzation of cancer cells in tumour angiogenesis. Importantly, we are also developing totally new strategies based on our lab’s findings for the treatment of cancer. Given the majority of cancer mortality arises from metastasis and it is only a very small fraction of cancer cells being able to metastasize, our lab’s current focus is on the exciting future of the identification of single cancer cells and single cell signalling at real-time in live cells both in vitro and in vivo.

The project titles are listed below:

  1. Single live cell TGF-b signalling in tumour and normal cells
  2. Dynamic TGF-b signalling during tumour invasion, circulation and metastasis
  3. Targeting TGF-b to improve cancer vaccination
  4. Single live cell Stat3 signalling in tumour and normal cells
  5. Molecular regulation of tumor cell plasticity (stem-ness-like)


Faculty Research Themes

Cancer

School Research Themes

Cancer in Medicine



Research Opportunities

PhD, Masters by Research, Honours, Master of Biomedical Science
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department

Surgery

Research Group / Unit / Centre

Cancer Signalling Research Laboratory

Research Node

Royal Melbourne Hospital

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