Regulating the vascularisation of the human glomerulus in vitro.

Research Opportunity
PhD students
Department / Centre
Paediatrics
Location
Royal Children’s Hospital/Murdoch Childrens Research Institute
Primary Supervisor Email Number Webpage
Prof Melissa Little melissa.little@mcri.edu.au Personal web page
Co-supervisor Email Number Webpage
Dr Aude Dorison aude.dorison@mcri.edu.au

Summary Regulating the vascularisation of the human glomerulus in vitro.

Project Details

The human kidney contains approximately 1 million nephrons each of which is comprised of a glomerulus into which a capillary bed grows and through which the blood is subsequently filtered to form the urine. We have development a model of the developing human kidney generated from human pluripotent stem cells that contains forming nephrons with maturing glomeruli as well as endothelial cells. However, the efficient with which capillary loops form within these glomeruli is low.

This project will investigate molecular approaches to induce growth factor secretion from the glomerulus to improve capillary formation in vitro. This will allow the modelling of glomerular kidney disease and potentially improve tissue survival post transplantation.



Faculty Research Themes

School Research Themes

Child Health in Medicine



Research Opportunities

PhD students
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research

Graduate Research application

Honours application

Key Contact

For further information about this research, please contact a supervisor.

Department / Centre

Paediatrics

Research Node

Royal Children’s Hospital/Murdoch Childrens Research Institute

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