Regulating the vascularisation of the human glomerulus in vitro.
- Research Opportunity
- PhD students
- Department / Centre
- Royal Children’s Hospital/Murdoch Childrens Research Institute
|Prof Melissa Littlefirstname.lastname@example.org||Personal web page|
|Dr Aude Dorisonemail@example.com|
Summary Regulating the vascularisation of the human glomerulus in vitro.
The human kidney contains approximately 1 million nephrons each of which is comprised of a glomerulus into which a capillary bed grows and through which the blood is subsequently filtered to form the urine. We have development a model of the developing human kidney generated from human pluripotent stem cells that contains forming nephrons with maturing glomeruli as well as endothelial cells. However, the efficient with which capillary loops form within these glomeruli is low.
This project will investigate molecular approaches to induce growth factor secretion from the glomerulus to improve capillary formation in vitro. This will allow the modelling of glomerular kidney disease and potentially improve tissue survival post transplantation.
Faculty Research Themes
School Research Themes
Students who are interested in joining this project will need to consider their elegibility as well as other requirements before contacting the supervisor of this research
For further information about this research, please contact a supervisor.
Department / Centre
Research NodeRoyal Children’s Hospital/Murdoch Childrens Research Institute
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